HitPredict

Interactor 1: RPB1 (P24928)
DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)
Gene: POLR2A

Interactor 2: SMCA4 (P51532)
Transcription activator BRG1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA4) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4)
Gene: SMARCA4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.666

Property	Details
Experiments	11238380, 8895581, 9845365, 15999204
Identification Methods	biochemical, affinity chromatography technology
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016787 - hydrolase activity
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1970 Hs			1 1647
+	Mm
		444961 RPB1_MOUSE (1-1611): 0: 1858: 100.00		SMCA4_MOUSE (1-1647): 0: 1069: 96.66
+	Hs
		624815 RPB1_HUMAN (1-1611): 0: 1858: 100.00		SMCA2_HUMAN (1-1647): 0: 980: 71.69
+	Hs
		625053 RPB1_HUMAN (1-1611): 0: 1858: 100.00		CHD8_HUMAN (13-1523): 0: 711: 21.11
+	Sc
		375326 RPB1_YEAST (11-1592): 0: 1458: 48.49		STH1_YEAST (369-1559): 0: 789: 33.10
+	Sc
		375591 RPC1_YEAST (11-1471): 0: 1356: 32.85		STH1_YEAST (369-1559): 0: 789: 33.10
+	Sc
		501341 RPA1_YEAST (11-1472): 0: 1134: 22.98		STH1_YEAST (369-1559): 0: 789: 33.10
+	Hs
		229264 RPA1_HUMAN (960-1473): 4.35e-38: 159: 16.12		SMCA5_HUMAN (626-1631): 0: 835: 27.41
+	Dm
		375643 RPB1_DROME (1576-1967): 1.09e-22: 108: 46.33		BRM_DROME (211-1642): 0: 858: 53.26