HitPredict

Interactor 1: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Interactor 2: CEBPA (P49715)
CCAAT/enhancer-binding protein alpha (C/EBP alpha)
Gene: CEBPA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.688

Property	Details
Experiments	15107404, 11684017, 34002296, 34189442
Identification Methods	affinity chromatography technology, pull down, unspecified method
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005667 - transcription regulator complex GO:0006351 - DNA-templated transcription
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 298 Hs			1 358
+	Mm
		862806 CDK2_MOUSE (1-298): 1.06e-157: 445: 85.26		CEBPA_MOUSE (1-358): 4.3e-64: 209: 91.19
+	Hs
		414821 CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90		CEBPA_HUMAN (1-358): 1.35e-69: 223: 100.00
+	Mm
		509477 CDK1_MOUSE (1-289): 8.74e-143: 405: 66.21		CEBPA_MOUSE (1-358): 4.3e-64: 209: 91.19
+	Hs
		831111 CDK7_HUMAN (2-298): 9.81e-124: 359: 44.00		CEBPA_HUMAN (1-358): 1.35e-69: 223: 100.00
+	Hs
		625260 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		CEBPG_HUMAN (225-347): 4.57e-24: 98.3: 30.89
+	Hs
		297854 CDK16_HUMAN (1-286): 4.1e-107: 322: 55.40		SC24D_HUMAN (17-228): 1.75e-09: 61.3: 11.32