HitPredict

Interactor 1: APC (P25054)
Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5)
Gene: APC

Interactor 2: CYTSA (Q69YQ0)
Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein)
Gene: SPECC1L

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	20936779
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0007155 - cell adhesion
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 2843 Hs			1 1117
+	Hs
		521470 APC_HUMAN (1-2843): 0: 1316: 100.00		ACTN1_HUMAN (1009-1116): 3.96e-50: 194: 42.20
+	Hs
		626062 APC_HUMAN (1-2843): 0: 1316: 100.00		MYH10_HUMAN (213-1075): 1.21e-33: 143: 10.62
+	Hs
		626064 APC_HUMAN (1-2843): 0: 1316: 100.00		MYH11_HUMAN (342-1028): 7.19e-25: 114: 9.72
+	Hs
		1056862 MDC1_HUMAN (1750-2784): 3.28e-21: 104: 11.74		CYTSA_HUMAN (1-1117): 1.12e-71: 262: 100.00
+	Hs
		993278 TITIN_HUMAN (717-2430): 7.06e-29: 130: 7.55		ACTN3_HUMAN (1009-1115): 7.86e-51: 196: 40.74
+	Hs
		521586 TITIN_HUMAN (717-2430): 7.06e-29: 130: 7.55		ACTN1_HUMAN (1009-1116): 3.96e-50: 194: 42.20
+	Hs
		725681 TITIN_HUMAN (717-2430): 7.06e-29: 130: 7.55		ACTN2_HUMAN (1009-1115): 3.7e-48: 188: 41.67
+	Hs
		211629 TITIN_HUMAN (717-2430): 7.06e-29: 130: 7.55		ACTN4_HUMAN (1009-1116): 6.66e-48: 187: 41.28
+	Hs
		521599 CIC_HUMAN (722-2643): 2.1e-17: 92.4: 7.79		ACTN1_HUMAN (1009-1116): 3.96e-50: 194: 42.20
+	Hs
		724893 MICA3_HUMAN (1200-1800): 2.91e-09: 65.2: 13.62		MYH9_HUMAN (206-1087): 3.64e-34: 144: 11.77