HitPredict

Interactor 1: PWP2 (P25635)
Periodic tryptophan protein 2 (U three protein 1) (U3 small nucleolar RNA-associated protein 1) (U3 snoRNA-associated protein 1)
Gene: PWP2

Interactor 2: HAS1 (Q03532)
ATP-dependent RNA helicase HAS1 (EC 3.6.4.13) (Helicase associated with SET1 protein 1)
Gene: HAS1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.928

Property	Details
Experiments	31511893, 12150911, 37968396, 21825077, 21724601, 16429126
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	ANAPC4_WD40~DEAD
Common GO terms	GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0005730 - nucleolus GO:0030490 - maturation of SSU-rRNA GO:0030686 - 90S preribosome GO:0032040 - small-subunit processome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 923 Sc			1 505
+	Sc
		593593 PWP2_YEAST (1-923): 0: 650: 100.00		DBP4_YEAST (3-501): 9.9e-165: 486: 37.70
+	Sc
		415901 PWP2_YEAST (1-923): 0: 650: 100.00		DED1_YEAST (20-418): 1.09e-136: 409: 27.85
+	Sc
		635549 PWP2_YEAST (1-923): 0: 650: 100.00		SPB4_YEAST (56-488): 1.9e-61: 213: 33.41
+	Sc
		416039 COPA_YEAST (1-447): 1.7e-49: 192: 12.05		DED1_YEAST (20-418): 1.09e-136: 409: 27.85
+	Sc
		593727 UTP12_YEAST (1-122): 1.57e-21: 103: 15.20		DBP4_YEAST (3-501): 9.9e-165: 486: 37.70
+	Sc
		976892 UTP12_YEAST (1-122): 1.57e-21: 103: 15.20		HAS1_YEAST (1-505): 1.8e-165: 479: 100.00
+	Hs
		903549 WDR5_HUMAN (546-909): 5.2e-38: 147: 7.95		DDX18_HUMAN (2-492): 3.3e-139: 418: 59.76
+	Hs
		903410 WDR5_HUMAN (546-909): 5.2e-38: 147: 7.95		DDX17_HUMAN (4-478): 1.71e-134: 407: 29.31
+	Hs
		571382 WDR5_HUMAN (546-909): 5.2e-38: 147: 7.95		DDX5_HUMAN (4-449): 2.8e-131: 395: 30.22
+	Hs
		133956 WDR5_HUMAN (546-909): 5.2e-38: 147: 7.95		DDX3X_HUMAN (4-428): 1.25e-126: 385: 27.77
+	Hs
		1288337 SNR40_HUMAN (143-502): 1.03e-16: 84.7: 22.28		DDX18_HUMAN (2-492): 3.3e-139: 418: 59.76
+	Hs
		1271621 SNR40_HUMAN (143-502): 1.03e-16: 84.7: 22.28		DDX17_HUMAN (4-478): 1.71e-134: 407: 29.31
+	Hs
		571547 SNR40_HUMAN (143-502): 1.03e-16: 84.7: 22.28		DDX5_HUMAN (4-449): 2.8e-131: 395: 30.22
+	Hs
		1271679 NLE1_HUMAN (669-882): 5.38e-12: 71: 11.66		DDX17_HUMAN (4-478): 1.71e-134: 407: 29.31
+	Hs
		903437 WDR5_HUMAN (546-909): 5.2e-38: 147: 7.95		DDX27_HUMAN (44-441): 4.37e-71: 243: 37.04
+	Hs
		903507 WDR5_HUMAN (546-909): 5.2e-38: 147: 7.95		DDX47_HUMAN (1-411): 5.57e-74: 242: 36.96
+	Hs
		1288310 SNR40_HUMAN (143-502): 1.03e-16: 84.7: 22.28		DDX31_HUMAN (9-505): 3.72e-82: 274: 32.37
+	Hs
		1333547 NLE1_HUMAN (669-882): 5.38e-12: 71: 11.66		DDX31_HUMAN (9-505): 3.72e-82: 274: 32.37
+	Hs
		1288233 SNR40_HUMAN (143-502): 1.03e-16: 84.7: 22.28		DDX27_HUMAN (44-441): 4.37e-71: 243: 37.04
+	Hs
		1292666 NLE1_HUMAN (669-882): 5.38e-12: 71: 11.66		DDX27_HUMAN (44-441): 4.37e-71: 243: 37.04