HitPredict

Interactor 1: PSA2 (P25787)
Proteasome subunit alpha type-2 (Macropain subunit C3) (Multicatalytic endopeptidase complex subunit C3) (Proteasome component C3)
Gene: PSMA2

Interactor 2: CUL1 (Q13616)
Cullin-1 (CUL-1)
Gene: CUL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	16759355, 19193609, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 234 Hs			1 776
+	Hs
		656219 PSA5_HUMAN (1-233): 2.69e-97: 285: 30.96		CUL1_HUMAN (1-776): 0: 911: 100.00
+	Hs
		893665 PSA6_HUMAN (2-234): 2.68e-90: 267: 34.73		CUL1_HUMAN (1-776): 0: 911: 100.00
+	Hs
		156283 PSA7_HUMAN (6-231): 1.49e-89: 266: 36.52		CUL1_HUMAN (1-776): 0: 911: 100.00
+	Hs
		637411 PSA1_HUMAN (1-233): 1.31e-89: 266: 30.67		CUL1_HUMAN (1-776): 0: 911: 100.00
+	Hs
		637681 PSA2_HUMAN (1-234): 2.95e-97: 285: 100.00		CUL4A_HUMAN (7-776): 0: 781: 30.41
+	Hs
		638125 PSA4_HUMAN (4-211): 1.24e-42: 146: 38.68		CUL1_HUMAN (1-776): 0: 911: 100.00
+	Hs
		656220 PSA5_HUMAN (1-233): 2.69e-97: 285: 30.96		CUL3_HUMAN (9-776): 0: 748: 30.47
+	Hs
		156284 PSA7_HUMAN (6-231): 1.49e-89: 266: 36.52		CUL3_HUMAN (9-776): 0: 748: 30.47