HitPredict

Interactor 1: RBTN2 (P25791)
Rhombotin-2 (Cysteine-rich protein TTG-2) (LIM domain only protein 2) (LMO-2) (T-cell translocation protein 2)
Gene: LMO2

Interactor 2: ISL1 (P61371)
Insulin gene enhancer protein ISL-1 (Islet-1)
Gene: ISL1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9452425
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	LIM~LIM
Common GO terms	GO:0005634 - nucleus GO:0043425 - bHLH transcription factor binding GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0046872 - metal ion binding GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 158 Hs			1 349
+	Hs
		899930 ISL2_HUMAN (12-148): 1.24e-41: 143: 32.61		ISL1_HUMAN (1-349): 1.96e-89: 274: 100.00
+	Hs
		1148484 LHX8_HUMAN (24-148): 1.1e-47: 159: 33.60		ISL2_HUMAN (1-349): 3.08e-80: 250: 73.35
+	Hs
		839800 ISL2_HUMAN (12-148): 1.24e-41: 143: 32.61		LHX2_HUMAN (3-316): 1.86e-58: 195: 25.55
+	Ce
		104771 LIM7_CAEEL (14-147): 4.14e-45: 155: 33.82		LIN11_CAEEL (3-339): 2.15e-53: 182: 25.79
+	Hs
		822660 ISL2_HUMAN (12-148): 1.24e-41: 143: 32.61		LHX1_HUMAN (16-349): 3.6e-57: 192: 27.35
+	Hs
		903736 LHX8_HUMAN (24-148): 1.1e-47: 159: 33.60		LMO4_HUMAN (17-132): 4e-25: 101: 40.34
+	Hs
		903764 ISL2_HUMAN (12-148): 1.24e-41: 143: 32.61		LMO4_HUMAN (17-132): 4e-25: 101: 40.34
+	Hs
		1251421 ISL2_HUMAN (12-148): 1.24e-41: 143: 32.61		LMO3_HUMAN (17-134): 2.1e-24: 98.6: 38.84
+	Dm
		1368258 Q9VJ37_DROME (24-153): 1.03e-45: 158: 34.09		Q9VJ00_DROME (5-77): 4.67e-12: 68.8: 27.03
+	Dm
		114751 P92031_DROME (24-153): 1.22e-45: 157: 34.09		M9PD53_DROME (5-77): 3.6e-12: 69.2: 27.03
+	Dm
		112552 Q9VJ37_DROME (24-153): 1.03e-45: 158: 34.09		M9NCY1_DROME (5-77): 5.73e-12: 68.1: 27.03
+	Ce
		104772 LIM7_CAEEL (14-147): 4.14e-45: 155: 33.82		HM14_CAEEL (4-79): 1.8e-12: 69.6: 20.51
+	Hs
		1148497 LHX8_HUMAN (24-148): 1.1e-47: 159: 33.60		LHX6_HUMAN (5-74): 2.11e-09: 60.4: 22.86
+	Hs
		1283500 ISL2_HUMAN (12-148): 1.24e-41: 143: 32.61		LHX3_HUMAN (4-341): 2.69e-14: 75.4: 13.37
+	Hs
		1281161 ISL2_HUMAN (12-148): 1.24e-41: 143: 32.61		LHX4_HUMAN (4-73): 8.65e-14: 73.9: 26.76
+	Mm
		864805 ISL2_MOUSE (12-148): 2.2e-41: 143: 32.61		LHX4_MOUSE (4-73): 7.96e-14: 73.9: 26.76
+	Hs
		238115 ISL2_HUMAN (12-148): 1.24e-41: 143: 32.61		LMX1B_HUMAN (4-74): 2.12e-13: 72.7: 19.72
+	Mm
		839895 ISL1_MOUSE (22-148): 6.29e-41: 141: 34.38		LHX3_MOUSE (4-73): 5.14e-12: 68.5: 23.94
+	Dm
		114396 M9PCA3_DROME (9-154): 8.59e-41: 145: 32.65		M9PCA3_DROME (4-70): 2.41e-09: 60.8: 23.53