HitPredict

Interactor 1: NFKB1 (P25799)
Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (NF-kappa-B1 p84/NF-kappa-B1 p98) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]
Gene: NFKB1

Interactor 2: M3K8 (Q07174)
Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (Cancer Osaka thyroid oncogene) (Proto-oncogene c-Cot) (Serine/threonine-protein kinase cot) (Tumor progression locus 2) (TPL-2)
Gene: Map3k8

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	18270204, 16291755
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank~Pkinase, Ank_2~Pkinase
Common GO terms	GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 971 Mm			1 467
+	Rn
		404391 NFKB1_RAT (1-971): 0: 859: 93.32		KPCA_RAT (1-464): 8.42e-132: 397: 14.26
+	Rn
		812706 NFKB1_RAT (1-971): 0: 859: 93.32		AKT1_RAT (78-457): 2.44e-134: 397: 17.17
+	Hs
		587460 NFKB1_HUMAN (1-971): 0: 833: 86.26		M3K8_HUMAN (1-467): 1.08e-139: 410: 93.36
+	Hs
		783315 NFKB2_HUMAN (24-921): 0: 593: 43.06		M3K8_HUMAN (1-467): 1.08e-139: 410: 93.36
+	Hs
		783318 TF65_HUMAN (28-409): 2.3e-128: 401: 36.82		M3K8_HUMAN (1-467): 1.08e-139: 410: 93.36
+	Hs
		783319 REL_HUMAN (33-551): 2.66e-123: 390: 29.94		M3K8_HUMAN (1-467): 1.08e-139: 410: 93.36
+	Hs
		682168 REL_HUMAN (33-551): 2.66e-123: 390: 29.94		AKT2_HUMAN (78-460): 8.99e-135: 398: 17.54
+	Hs
		961425 NFKB2_HUMAN (24-921): 0: 593: 43.06		M3K14_HUMAN (107-382): 3.26e-30: 126: 31.01
+	Hs
		408681 Q9H4D1_HUMAN (363-855): 2.95e-61: 225: 19.45		KPCB_HUMAN (1-460): 1.92e-131: 396: 15.11
+	Hs
		1330871 Q9H4D1_HUMAN (363-855): 2.95e-61: 225: 19.45		STK26_HUMAN (144-388): 5.24e-101: 310: 34.13
+	Hs
		981702 REL_HUMAN (33-551): 2.66e-123: 390: 29.94		M3K14_HUMAN (107-382): 3.26e-30: 126: 31.01
+	Hs
		566290 IKBA_HUMAN (457-650): 1.39e-24: 107: 22.50		KPCA_HUMAN (1-464): 1.79e-131: 396: 14.26
+	Hs
		639678 IKBA_HUMAN (457-650): 1.39e-24: 107: 22.50		AKT1_HUMAN (78-457): 1.34e-133: 395: 16.92
+	Hs
		408584 RIPK4_HUMAN (409-607): 4.95e-21: 101: 18.32		KPCB_HUMAN (1-460): 1.92e-131: 396: 15.11
+	Hs
		595660 BCL3_HUMAN (466-628): 9.45e-14: 76.7: 21.89		AKT1_HUMAN (78-457): 1.34e-133: 395: 16.92
+	Hs
		964521 RELB_HUMAN (32-473): 1.21e-106: 345: 33.63		M3K14_HUMAN (107-382): 3.26e-30: 126: 31.01
+	Hs
		639797 IKBA_HUMAN (457-650): 1.39e-24: 107: 22.50		M3K14_HUMAN (107-382): 3.26e-30: 126: 31.01
+	Hs
		862107 DAPK1_HUMAN (433-597): 2.14e-14: 80.3: 15.96		PAK6_HUMAN (110-388): 8.96e-27: 115: 30.53