Interactor 1: DDX6 (P26196)
Probable ATP-dependent RNA helicase DDX6 (EC 3.6.4.13) (ATP-dependent RNA helicase p54) (DEAD box protein 6) (Oncogene RCK)
Gene: DDX6

Interactor 2: AGO2 (Q9UKV8)
Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer)
Gene: AGO2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.85 0.60 0.716

The method score is based on:

Property Details
Experiments 29395067, 23535175, 22851315, 16756390, 28683311
Identification Methods proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation, fluorescent resonance energy transfer, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000932 - P-body
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
and 4 others

more...

Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 483
Hs

1 859
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Dm
+ Ce
+ Hs
+ Ce
+ Ce
+ Ce
+ Ce
+ Dr
+ Dm
+ Dm
+ Dm
+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024