Protein: ZP2
Zona pellucida sperm-binding protein 2 (Zona pellucida glycoprotein 2) (Zp-2) (Zona pellucida protein A) [Cleaved into: Processed zona pellucida sperm-binding protein 2]

Gene: ZP2
Organism: Homo sapiens
Interactions: 21
UniProt ID: Q05996

Gene Ontology (top 5):
GO:0005576 - extracellular region
GO:0005771 - multivesicular body
GO:0005783 - endoplasmic reticulum
GO:0005886 - plasma membrane
GO:0007339 - binding of sperm to zona pellucida

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

640661

ZP3
Zona pellucida sperm-binding protein 3

2

10

Small-scale

0.712

High

1053183

ZP2
Zona pellucida sperm-binding protein 2

1

10

Small-scale

0.701

High

954065

ZP1
Zona pellucida sperm-binding protein 1

1

10

Small-scale

0.575

High

1053184

ZP4
Zona pellucida sperm-binding protein 4

1

10

Small-scale

0.575

High

852731

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

2

Small-scale

0.515

High

1053185

EXT1
Exostosin-1

1

0

High-throughput

0.513

High

521063

ACRO
Acrosin

1

5

Small-scale

0.501

High

445834

ENOA
Alpha-enolase

1

2

Small-scale

0.479

High

573075

KPYM
Pyruvate kinase PKM

1

2

Small-scale

0.479

High

557248

SRC
Proto-oncogene tyrosine-protein kinase Src

1

0

High-throughput

0.458

High

619034

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

0

High-throughput

0.458

High

156259

G3PT
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

1

2

Small-scale

0.437

High

788301

GPX4
Phospholipid hydroperoxide glutathione peroxidase GPX4

1

2

Small-scale

0.437

High

322721

RHBT3
Rho-related BTB domain-containing protein 3

1

0

High-throughput

0.279

Low

789634

HPCL1
Hippocalcin-like protein 1

1

0

High-throughput

0.279

Low

890820

TSC2
Tuberin

1

0

High-throughput

0.279

Low

1053186

UBR3
E3 ubiquitin-protein ligase UBR3

1

0

High-throughput

0.279

Low

1053187

FACR2
Fatty acyl-CoA reductase 2

1

0

High-throughput

0.279

Low

1053188

INT7
Integrator complex subunit 7

1

0

High-throughput

0.279

Low

990132

1433Z
14-3-3 protein zeta/delta

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025