Protein: ZP3
Zona pellucida sperm-binding protein 3 (Sperm receptor) (ZP3A/ZP3B) (Zona pellucida glycoprotein 3) (Zp-3) (Zona pellucida protein C) [Cleaved into: Processed zona pellucida sperm-binding protein 3]

Gene: ZP3
Organism: Homo sapiens
Interactions: 26
UniProt ID: P21754

Gene Ontology (top 5):
GO:0001809 - positive regulation of type IV hypersensitivity
GO:0001825 - blastocyst formation
GO:0002455 - humoral immune response mediated by circulating immunoglobulin
GO:0002687 - positive regulation of leukocyte migration
GO:0002922 - positive regulation of humoral immune response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

640655

ZP3
Zona pellucida sperm-binding protein 3

2

10

Small-scale

0.804

High

640660

ZP1
Zona pellucida sperm-binding protein 1

2

10

Small-scale

0.712

High

640661

ZP2
Zona pellucida sperm-binding protein 2

2

10

Small-scale

0.712

High

284483

CLD11
Claudin-11

2

0

High-throughput

0.580

High

640663

MALL
MAL-like protein

2

0

High-throughput

0.580

High

640662

ZP4
Zona pellucida sperm-binding protein 4

1

10

Small-scale

0.575

High

167734

PCD17
Protocadherin-17

1

0

Small-scale

0.518

High

640664

UBP2L
Ubiquitin-associated protein 2-like

1

0

Small-scale

0.518

High

640667

SACA3
Sperm acrosome membrane-associated protein 3

1

0

Small-scale

0.518

High

640657

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

2

Small-scale

0.515

High

640658

SPB8
Serpin B8

1

0

High-throughput

0.513

High

521060

ACRO
Acrosin

1

5

Small-scale

0.501

High

445734

ENOA
Alpha-enolase

1

2

Small-scale

0.479

High

572987

KPYM
Pyruvate kinase PKM

1

2

Small-scale

0.479

High

640659

TPIS
Triosephosphate isomerase

1

1

Small-scale

0.479

High

640668

OR2LD
Olfactory receptor 2L13

1

0

Small-scale

0.460

High

156238

G3PT
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

1

2

Small-scale

0.437

High

636816

GSTM3
Glutathione S-transferase Mu 3

1

1

Small-scale

0.437

High

640656

GPX4
Phospholipid hydroperoxide glutathione peroxidase GPX4

1

2

Small-scale

0.437

High

640665

ODFP2
Outer dense fiber protein 2

1

2

Small-scale

0.437

High

640669

MILK1
MICAL-like protein 1

1

0

Small-scale

0.282

High

640666

GET4
Golgi to ER traffic protein 4 homolog

1

0

High-throughput

0.279

Low

640670

MINY1
Ubiquitin carboxyl-terminal hydrolase MINDY-1

1

0

High-throughput

0.279

Low

640672

RT16
Small ribosomal subunit protein bS16m

1

0

Small-scale

0.251

Low

640671

HECW2
E3 ubiquitin-protein ligase HECW2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025