HitPredict

Interactor 1: DNMT1 (P26358)
DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT)
Gene: DNMT1

Interactor 2: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35271311, 15161933
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1616 Hs			1 245
+	Hs
		641183 DNMT1_HUMAN (1-1616): 0: 1717: 100.00		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		641151 DNMT1_HUMAN (1-1616): 0: 1717: 100.00		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		641181 DNMT1_HUMAN (1-1616): 0: 1717: 100.00		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		641200 DNMT1_HUMAN (1-1616): 0: 1717: 100.00		1433F_HUMAN (2-240): 1.26e-107: 312: 74.49
+	Xl
		945535 P79922_XENLA (126-1616): 0: 1502: 70.07		Q6PGS3_XENLA (1-245): 4.5e-139: 391: 88.57
+	Xl
		945475 P79922_XENLA (126-1616): 0: 1502: 70.07		143BA_XENLA (1-242): 2.85e-127: 362: 85.12
+	Xl
		945566 P79922_XENLA (126-1616): 0: 1502: 70.07		Q7ZXH6_XENLA (1-245): 5.91e-114: 328: 75.10
+	Hs
		297824 K0754_HUMAN (15-605): 2.22e-18: 94.4: 10.73		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		297821 K0754_HUMAN (15-605): 2.22e-18: 94.4: 10.73		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		297815 K0754_HUMAN (15-605): 2.22e-18: 94.4: 10.73		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60