Protein: TIE2
Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b)

Gene: TIE2, TEK
Organism: Homo sapiens
Interactions: 117
UniProt ID: Q02763

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0001935 - endothelial cell proliferation
GO:0001938 - positive regulation of endothelial cell proliferation
GO:0002040 - sprouting angiogenesis
GO:0004672 - protein kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

178676

ANGP2
Angiopoietin-2

7

6

Small-scale

0.973

High

1038438

ANGP1
Angiopoietin-1

6

6

Small-scale

0.947

High

1038488

ANGP4
Angiopoietin-4

2

6

Small-scale

0.778

High

711312

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.770

High

658819

PTPRB
Receptor-type tyrosine-protein phosphatase beta

2

19

Small-scale

0.712

High

1038428

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

20

High-throughput

0.698

High

1038436

PTPRR
Receptor-type tyrosine-protein phosphatase R

1

20

High-throughput

0.698

High

1038456

DUS18
Dual specificity protein phosphatase 18

1

18

High-throughput

0.698

High

1038459

STYX
Serine/threonine/tyrosine-interacting protein

1

18

High-throughput

0.698

High

1038446

SHC4
SHC-transforming protein 4

1

20

Small-scale

0.692

High

631641

RAB6A
Ras-related protein Rab-6A

1

9

High-throughput

0.691

High

691710

MK03
Mitogen-activated protein kinase 3

1

6

High-throughput

0.691

High

421957

A4
Amyloid-beta precursor protein

1

12

High-throughput

0.647

High

1038424

TIE2
Angiopoietin-1 receptor

1

18

Small-scale

0.647

High

484109

PGFRB
Platelet-derived growth factor receptor beta

1

20

High-throughput

0.646

High

543182

UBL4A
Ubiquitin-like protein 4A

1

11

High-throughput

0.646

High

856648

BAG6
Large proline-rich protein BAG6

1

7

High-throughput

0.646

High

1038439

CDC37
Hsp90 co-chaperone Cdc37

1

20

High-throughput

0.646

High

1038471

NUD12
NAD-capped RNA hydrolase NUDT12

1

20

High-throughput

0.646

High

1038433

PWP1
Periodic tryptophan protein 1 homolog

1

10

High-throughput

0.618

High

193257

SOCS1
Suppressor of cytokine signaling 1

1

20

Small-scale

0.618

High

410781

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.618

High

507855

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

9

High-throughput

0.618

High

651284

CBL
E3 ubiquitin-protein ligase CBL

1

20

Small-scale

0.618

High

773344

TIE1
Tyrosine-protein kinase receptor Tie-1

1

19

Small-scale

0.618

High

249749

DOK2
Docking protein 2

2

20

Small-scale

0.584

High

471739

PTPRC
Receptor-type tyrosine-protein phosphatase C

1

20

High-throughput

0.575

High

659017

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

1

18

High-throughput

0.575

High

1038427

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

20

High-throughput

0.575

High

1038431

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

1

20

High-throughput

0.575

High

1038437

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

17

High-throughput

0.575

High

1038441

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

18

High-throughput

0.575

High

1038425

CAV1
Caveolin-1

1

7

Small-scale

0.561

High

1038491

NEMO
NF-kappa-B essential modulator

1

14

High-throughput

0.561

High

1038457

TNIP2
TNFAIP3-interacting protein 2

1

0

Small-scale

0.549

High

1038475

ILKAP
Integrin-linked kinase-associated serine/threonine phosphatase 2C

1

7

High-throughput

0.541

High

122756

KIF2A
Kinesin-like protein KIF2A

1

1

High-throughput

0.536

High

220899

XPOT
Exportin-T

1

7

High-throughput

0.536

High

221564

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

5

High-throughput

0.536

High

243606

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

4

High-throughput

0.536

High

333995

SMC2
Structural maintenance of chromosomes protein 2

1

11

High-throughput

0.536

High

608867

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

10

High-throughput

0.536

High

612202

ARF4
ADP-ribosylation factor 4

1

14

High-throughput

0.536

High

627638

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

4

High-throughput

0.536

High

703295

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

1

4

High-throughput

0.536

High

834429

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

7

High-throughput

0.536

High

894692

EMD
Emerin

1

10

High-throughput

0.536

High

957714

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

7

High-throughput

0.536

High

1008096

PRKDC
DNA-dependent protein kinase catalytic subunit

1

13

High-throughput

0.536

High

1038430

NSUN2
RNA cytosine C(5)-methyltransferase NSUN2

1

6

High-throughput

0.536

High

1038432

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

1

High-throughput

0.536

High

1038434

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

3

High-throughput

0.536

High

1038444

RIF1
Telomere-associated protein RIF1

1

2

High-throughput

0.536

High

1038445

SKI3
Superkiller complex protein 3

1

2

High-throughput

0.536

High

1038447

KCNT2
Potassium channel subfamily T member 2

1

4

High-throughput

0.536

High

1038448

POGZ
Pogo transposable element with ZNF domain

1

1

High-throughput

0.536

High

1038449

MYH14
Myosin-14

1

4

High-throughput

0.536

High

1038454

NUP93
Nuclear pore complex protein Nup93

1

5

High-throughput

0.536

High

1038458

DDX54
ATP-dependent RNA helicase DDX54

1

13

High-throughput

0.536

High

1038460

DNJC9
DnaJ homolog subfamily C member 9

1

20

High-throughput

0.536

High

1038462

RT27
Small ribosomal subunit protein mS27

1

1

High-throughput

0.536

High

1038464

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

6

High-throughput

0.536

High

1038467

DDX27
Probable ATP-dependent RNA helicase DDX27

1

13

High-throughput

0.536

High

1038468

RBM14
RNA-binding protein 14

1

11

High-throughput

0.536

High

1038473

GTPB4
GTP-binding protein 4

1

1

High-throughput

0.536

High

1038474

NAT10
RNA cytidine acetyltransferase

1

2

High-throughput

0.536

High

1038477

YTDC2
3'-5' RNA helicase YTHDC2

1

3

High-throughput

0.536

High

1038480

MDN1
Midasin

1

10

High-throughput

0.536

High

1038483

ABCF2
ATP-binding cassette sub-family F member 2

1

2

High-throughput

0.536

High

1038485

BAZ1B
Tyrosine-protein kinase BAZ1B

1

10

High-throughput

0.536

High

1038486

MRT4
mRNA turnover protein 4 homolog

1

4

High-throughput

0.536

High

1038489

HYOU1
Hypoxia up-regulated protein 1

1

20

High-throughput

0.536

High

1038490

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

1

2

High-throughput

0.536

High

584861

NQO1
NAD(P)H dehydrogenase [quinone] 1

1

0

High-throughput

0.513

High

1038451

SLN11
Schlafen family member 11

1

0

High-throughput

0.513

High

228475

LANC1
Glutathione S-transferase LANCL1

1

2

High-throughput

0.500

High

276773

TBCA
Tubulin-specific chaperone A

1

1

High-throughput

0.500

High

369664

A2MG
Alpha-2-macroglobulin

1

1

High-throughput

0.500

High

389734

FETUA
Alpha-2-HS-glycoprotein

1

3

High-throughput

0.500

High

446408

G6PI
Glucose-6-phosphate isomerase

1

2

High-throughput

0.500

High

488460

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

4

High-throughput

0.500

High

681343

PSA3
Proteasome subunit alpha type-3

1

3

High-throughput

0.500

High

717290

PEBP1
Phosphatidylethanolamine-binding protein 1

1

5

High-throughput

0.500

High

976992

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

2

High-throughput

0.500

High

1038426

LGUL
Lactoylglutathione lyase

1

2

High-throughput

0.500

High

1038450

YTHD3
YTH domain-containing family protein 3

1

13

High-throughput

0.500

High

1038469

PSB7
Proteasome subunit beta type-7

1

2

High-throughput

0.500

High

137704

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

7

High-throughput

0.489

High

277655

H2AY
Core histone macro-H2A.1

1

6

High-throughput

0.489

High

338110

NSA2
Ribosome biogenesis protein NSA2 homolog

1

2

High-throughput

0.489

High

426254

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

6

High-throughput

0.489

High

863459

STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

1

4

High-throughput

0.489

High

1011253

RT25
Small ribosomal subunit protein mS25

1

2

High-throughput

0.489

High

1012811

RT09
Small ribosomal subunit protein uS9m

1

3

High-throughput

0.489

High

1038429

SSRP1
FACT complex subunit SSRP1

1

4

High-throughput

0.489

High

1038435

RRS1
Ribosome biogenesis regulatory protein homolog

1

2

High-throughput

0.489

High

1038442

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

6

High-throughput

0.489

High

1038443

ZN326
DBIRD complex subunit ZNF326

1

5

High-throughput

0.489

High

1038452

ZCH18
Zinc finger CCCH domain-containing protein 18

1

4

High-throughput

0.489

High

1038453

PHF6
PHD finger protein 6

1

9

High-throughput

0.489

High

1038455

KRI1
Protein KRI1 homolog

1

11

High-throughput

0.489

High

1038461

ELYS
Protein ELYS

1

9

High-throughput

0.489

High

1038463

NU205
Nuclear pore complex protein Nup205

1

7

High-throughput

0.489

High

1038470

EBP2
Probable rRNA-processing protein EBP2

1

1

High-throughput

0.489

High

1038476

CCD86
Coiled-coil domain-containing protein 86

1

2

High-throughput

0.489

High

1038478

SAR1A
Small COPII coat GTPase SAR1A

1

20

High-throughput

0.489

High

1038479

BAZ1A
Bromodomain adjacent to zinc finger domain protein 1A

1

14

High-throughput

0.489

High

1038481

RBM28
RNA-binding protein 28

1

7

High-throughput

0.489

High

1038484

BAZ2A
Bromodomain adjacent to zinc finger domain protein 2A

1

20

High-throughput

0.489

High

1038487

WDR3
WD repeat-containing protein 3

1

3

High-throughput

0.489

High

361877

HPRT
Hypoxanthine-guanine phosphoribosyltransferase

1

0

High-throughput

0.479

High

1038440

CP1B1
Cytochrome P450 1B1

1

2

Small-scale

0.479

High

1038465

RM24
Large ribosomal subunit protein uL24m

1

0

High-throughput

0.279

Low

1038472

CHOLN
Protein cholesin

1

0

High-throughput

0.279

Low

1038482

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.279

Low

1038466

BORC7
BLOC-1-related complex subunit 7

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025