Interactor 1: SDHB (P21912)
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC 1.3.5.1) (Iron-sulfur subunit of complex II) (Ip) (Malate dehydrogenase [quinone] iron-sulfur subunit) (EC 1.1.5.-)
Gene: SDHB
Interactor 2: SDHA (P31040)
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC 1.3.5.1) (Flavoprotein subunit of complex II) (Fp) (Malate dehydrogenase [quinone] flavoprotein subunit) (EC 1.1.5.-)
Gene: SDHA
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.94 | 1.00 | 0.970 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 37071682, 38334954, 31839598, 28514442, 33961781, 35235311, 40437099, 26749241, 24606901, 19688755 |
| Identification Methods | cross-linking study, affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, blue native page |
| Interaction Type | physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | FAD_binding_2~Fer2_3, Fer2_3~Succ_DH_flav_C, FAD_binding_2~Fer4_17 |
| Common GO terms | GO:0005739 - mitochondrion GO:0005743 - mitochondrial inner membrane GO:0005759 - mitochondrial matrix GO:0006099 - tricarboxylic acid cycle GO:0006105 - succinate metabolic process and 6 others more... |
| Homologous interactions | 7 |
Homologous interactions
Color coding for hit scores 
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| + | Hp | |
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| + | Nv | |
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
