HitPredict

Interactor 1: PGFRA (P26618)
Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (Platelet-derived growth factor alpha receptor) (CD antigen CD140a)
Gene: Pdgfra

Interactor 2: SHB (Q6PD21)
SH2 domain-containing adapter protein B
Gene: SHB

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	10837138
Identification Methods	coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005654 - nucleoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1089 Mm			1 503
+	Rn
		595729 PGFRA_RAT (1-1089): 0: 863: 95.96		LYN_RAT (272-501): 3.24e-55: 194: 15.19
+	Hs
		557172 PGFRA_HUMAN (1-1089): 0: 853: 91.83		SHF_HUMAN (156-503): 5.15e-50: 178: 39.47
+	Hs
		557088 PGFRA_HUMAN (1-1089): 0: 853: 91.83		GRB2_HUMAN (341-484): 1.01e-21: 95.3: 19.73
+	Hs
		208979 PGFRB_HUMAN (29-1089): 0: 653: 43.12		NCK2_HUMAN (154-499): 1.62e-89: 280: 17.71
+	Hs
		452344 PGFRB_HUMAN (29-1089): 0: 653: 43.12		NCK1_HUMAN (154-498): 8.86e-80: 255: 16.81
+	Mm
		404012 PGFRB_MOUSE (29-1089): 0: 670: 43.58		FYN_MOUSE (270-500): 1.57e-53: 190: 13.87
+	Hs
		433221 PGFRB_HUMAN (29-1089): 0: 653: 43.12		YES_HUMAN (246-494): 1.61e-56: 199: 16.41
+	Hs
		452338 PGFRB_HUMAN (29-1089): 0: 653: 43.12		SRC_HUMAN (258-494): 8.21e-57: 199: 17.67
+	Hs
		411953 PGFRB_HUMAN (29-1089): 0: 653: 43.12		FYN_HUMAN (270-500): 1.57e-53: 190: 13.87
+	Mm
		403408 CSF1R_MOUSE (1-952): 0: 612: 30.69		SRC_MOUSE (258-494): 9.52e-59: 204: 17.34
+	Mm
		452181 CSF1R_MOUSE (1-952): 0: 612: 30.69		FYN_MOUSE (270-500): 1.57e-53: 190: 13.87
+	Hs
		426975 CSF1R_HUMAN (1-956): 0: 597: 30.87		YES_HUMAN (246-494): 1.61e-56: 199: 16.41
+	Hs
		426981 CSF1R_HUMAN (1-956): 0: 597: 30.87		SRC_HUMAN (258-494): 8.21e-57: 199: 17.67
+	Hs
		426976 CSF1R_HUMAN (1-956): 0: 597: 30.87		LYN_HUMAN (272-501): 9.76e-56: 195: 15.19
+	Hs
		337317 PGFRB_HUMAN (29-1089): 0: 653: 43.12		ABL1_HUMAN (348-501): 1.13e-32: 134: 23.38
+	Hs
		411943 CSF1R_HUMAN (1-956): 0: 597: 30.87		FYN_HUMAN (270-500): 1.57e-53: 190: 13.87
+	Hs
		452370 PGFRB_HUMAN (29-1089): 0: 653: 43.12		ABL2_HUMAN (348-481): 9.28e-33: 134: 26.12
+	Mm
		404013 PGFRB_MOUSE (29-1089): 0: 670: 43.58		GRB2_MOUSE (341-484): 1.01e-21: 95.3: 19.73
+	Hs
		452385 PGFRB_HUMAN (29-1089): 0: 653: 43.12		GRB2_HUMAN (341-484): 1.01e-21: 95.3: 19.73
+	Hs
		275162 CSF1R_HUMAN (1-956): 0: 597: 30.87		GRAP2_HUMAN (341-484): 5.26e-20: 93: 23.97