HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction GO:0016020 - membrane GO:0032991 - protein-containing complex and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 304
+	Mm
		910263 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		CRK_MOUSE (1-304): 5.53e-68: 215: 99.67
+	Mm
		926808 1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00		CRK_MOUSE (1-304): 5.53e-68: 215: 99.67
+	Hs
		802560 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Mm
		933127 1433T_MOUSE (1-245): 2.96e-141: 397: 99.59		CRK_MOUSE (1-304): 5.53e-68: 215: 99.67
+	Hs
		909706 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		DNMBP_HUMAN (119-293): 5.7e-46: 168: 29.35
+	Mm
		1144843 1433B_MOUSE (1-242): 2.84e-124: 354: 80.99		CRK_MOUSE (1-304): 5.53e-68: 215: 99.67
+	Hs
		647023 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		DNMBP_HUMAN (119-293): 5.7e-46: 168: 29.35
+	Hs
		927191 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		DNMBP_HUMAN (119-293): 5.7e-46: 168: 29.35
+	Hs
		683469 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		DNMBP_HUMAN (119-293): 5.7e-46: 168: 29.35
+	Hs
		275184 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		GRAP2_HUMAN (1-296): 5.17e-33: 125: 17.17
+	Hs
		683888 1433S_HUMAN (1-236): 9.86e-108: 312: 71.85		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Mm
		935515 1433F_MOUSE (2-242): 4.62e-106: 308: 71.43		CRK_MOUSE (1-304): 5.53e-68: 215: 99.67
+	Hs
		909427 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		646781 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		924450 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Dm
		954994 1433E_DROME (2-242): 6.77e-143: 401: 65.02		GRAP_DROME (135-293): 4.02e-23: 96.4: 16.43
+	Dm
		664604 1433Z_DROME (1-245): 3.68e-141: 397: 77.14		GRAP_DROME (135-293): 4.02e-23: 96.4: 16.43
+	Hs
		683253 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		684142 1433S_HUMAN (1-236): 9.86e-108: 312: 71.85		DNMBP_HUMAN (119-293): 5.7e-46: 168: 29.35
+	Hs
		684429 1433S_HUMAN (1-236): 9.86e-108: 312: 71.85		CD2AP_HUMAN (1-196): 4.74e-12: 68.3: 17.12