HitPredict

Interactor 1: RHG32 (A7KAX9)
Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP)
Gene: ARHGAP32

Interactor 2: SHC3 (Q92529)
SHC-transforming protein 3 (Neuronal Shc) (N-Shc) (Protein Rai) (SHC-transforming protein C) (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3)
Gene: SHC3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	12446789
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2087 Hs			1 594
+	Hs
		64661 RHG32_HUMAN (1-2087): 0: 1424: 100.00		SHC1_HUMAN (3-593): 5.76e-176: 512: 46.65
+	Hs
		64693 RHG32_HUMAN (1-2087): 0: 1424: 100.00		SHC2_HUMAN (47-593): 4.99e-147: 438: 43.96
+	Hs
		64648 RHG32_HUMAN (1-2087): 0: 1424: 100.00		SRC_HUMAN (361-594): 3.73e-49: 181: 18.18
+	Hs
		64642 RHG32_HUMAN (1-2087): 0: 1424: 100.00		FYN_HUMAN (438-585): 3.12e-44: 167: 20.76
+	Hs
		64643 RHG32_HUMAN (1-2087): 0: 1424: 100.00		LYN_HUMAN (404-594): 8.1e-44: 165: 20.69
+	Hs
		64687 RHG32_HUMAN (1-2087): 0: 1424: 100.00		GRB2_HUMAN (445-594): 1.28e-34: 132: 22.08
+	Hs
		64651 RHG32_HUMAN (1-2087): 0: 1424: 100.00		NCK1_HUMAN (478-586): 2.54e-13: 73.7: 24.56
+	Mm
		763398 RHG33_MOUSE (73-1289): 3.48e-114: 398: 30.65		FYN_MOUSE (438-585): 3.12e-44: 167: 20.76
+	Hs
		147859 RHG33_HUMAN (74-1276): 2.2e-113: 395: 30.98		FYN_HUMAN (438-585): 3.12e-44: 167: 20.76
+	Mm
		1206665 SRGP2_MOUSE (191-939): 8.66e-75: 274: 16.09		ANS1B_MOUSE (11-331): 1.47e-68: 243: 17.68
+	Hs
		561393 RHG21_HUMAN (88-1152): 8.55e-69: 260: 14.84		FER_HUMAN (424-594): 2.65e-47: 179: 25.43
+	Hs
		523026 RHG17_HUMAN (189-1018): 1.7e-69: 255: 14.81		SRC_HUMAN (361-594): 3.73e-49: 181: 18.18
+	Hs
		433814 RHG21_HUMAN (88-1152): 8.55e-69: 260: 14.84		LYN_HUMAN (404-594): 8.1e-44: 165: 20.69
+	Hs
		433879 RHG12_HUMAN (312-568): 5.13e-71: 259: 28.68		LYN_HUMAN (404-594): 8.1e-44: 165: 20.69
+	Hs
		200212 SRGP3_HUMAN (294-939): 5.72e-78: 284: 17.36		GRB2_HUMAN (445-594): 1.28e-34: 132: 22.08
+	Hs
		924608 Q1RLN5_HUMAN (312-568): 8.43e-72: 260: 28.68		GRB2_HUMAN (445-594): 1.28e-34: 132: 22.08
+	Hs
		924686 RHG12_HUMAN (312-568): 5.13e-71: 259: 28.68		GRB2_HUMAN (445-594): 1.28e-34: 132: 22.08
+	Hs
		924636 RHG17_HUMAN (189-1018): 1.7e-69: 255: 14.81		GRB2_HUMAN (445-594): 1.28e-34: 132: 22.08
+	Hs
		557642 CHIO_HUMAN (367-567): 2.05e-76: 264: 33.66		NCK1_HUMAN (478-586): 2.54e-13: 73.7: 24.56
+	Hs
		557714 RHG21_HUMAN (88-1152): 8.55e-69: 260: 14.84		NCK1_HUMAN (478-586): 2.54e-13: 73.7: 24.56