HitPredict

Interactor 1: FGFR3 (P22607)
Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)
Gene: FGFR3

Interactor 2: KLOTB (Q86Z14)
Beta-klotho (BKL) (BetaKlotho) (Klotho beta-like protein)
Gene: KLB

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17623664
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Glyco_hydro_1~I-set, Glyco_hydro_1~Ig_3
Common GO terms	GO:0005886 - plasma membrane GO:0008284 - positive regulation of cell population proliferation GO:0017134 - fibroblast growth factor binding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 806 Hs			1 1044
+	Hs
		541576 FGFR1_HUMAN (1-114): 5.62e-13: 74.7: 18.32		KLOTB_HUMAN (1-1044): 0: 1398: 100.00
+	Hs
		648577 FGFR4_HUMAN (1-130): 1.38e-11: 70.1: 17.93		KLOTB_HUMAN (1-1044): 0: 1398: 100.00
+	Hs
		641206 FGFR2_HUMAN (1-137): 5.98e-11: 68.2: 18.18		KLOTB_HUMAN (1-1044): 0: 1398: 100.00
+	Mm
		591455 FGFR1_MOUSE (1-114): 5.86e-13: 74.7: 18.32		KLOTB_MOUSE (1-1044): 0: 1354: 78.76
+	Mm
		1041419 FGFR4_MOUSE (1-130): 8.15e-12: 70.9: 17.24		KLOTB_MOUSE (1-1044): 0: 1354: 78.76
+	Mm
		204195 FGFR1_MOUSE (1-114): 5.86e-13: 74.7: 18.32		KLOT_MOUSE (55-1025): 0: 1166: 45.83
+	Mm
		204202 FGFR3_MOUSE (1-153): 2.42e-12: 72.8: 16.47		KLOT_MOUSE (55-1025): 0: 1166: 45.83
+	Mm
		204201 FGFR4_MOUSE (1-130): 8.15e-12: 70.9: 17.24		KLOT_MOUSE (55-1025): 0: 1166: 45.83
+	Mm
		98382 E9QNJ9_MOUSE (1-114): 1.06e-11: 70.5: 17.69		KLOT_MOUSE (55-1025): 0: 1166: 45.83
+	Mm
		204197 FGFR2_MOUSE (1-137): 3.43e-10: 65.9: 16.88		KLOT_MOUSE (55-1025): 0: 1166: 45.83
+	Ce
		1083547 EGL15_CAEEL (46-248): 2.03e-22: 105: 18.78		Q18758_CAEEL (521-963): 5.37e-156: 472: 24.44