Protein: KLOTB
Beta-klotho (BKL) (BetaKlotho) (Klotho beta-like protein)

Gene: KLOTB, KLB
Organism: Homo sapiens
Interactions: 12
UniProt ID: Q86Z14

Gene Ontology (top 5):
GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0005104 - fibroblast growth factor receptor binding
GO:0005886 - plasma membrane
GO:0005975 - carbohydrate metabolic process
GO:0008284 - positive regulation of cell population proliferation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

541576

FGFR1
Fibroblast growth factor receptor 1

4

11

Small-scale

0.882

High

1295752

FGF21
Fibroblast growth factor 21

1

1

Small-scale

0.647

High

641206

FGFR2
Fibroblast growth factor receptor 2

1

11

Small-scale

0.618

High

648577

FGFR4
Fibroblast growth factor receptor 4

1

11

Small-scale

0.618

High

650277

FGFR3
Fibroblast growth factor receptor 3

1

11

Small-scale

0.618

High

1007121

TCPB
T-complex protein 1 subunit beta

1

1

High-throughput

0.470

High

331113

KI20A
Kinesin-like protein KIF20A

1

2

High-throughput

0.437

High

1295751

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

1

High-throughput

0.437

High

948872

CD81
CD81 antigen

1

0

High-throughput

0.426

High

986544

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.269

Low

1295750

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

765680

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025