HitPredict

Interactor 1: RFA1 (P27694)
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]
Gene: RPA1

Interactor 2: KS6A3 (P51812)
Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2)
Gene: RPS6KA3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	37827155
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 616 Hs			1 740
+	Hs
		651283 RFA1_HUMAN (1-616): 0: 781: 100.00		KS6A1_HUMAN (1-740): 0: 783: 77.90
+	Hs
		652560 RFA1_HUMAN (1-616): 0: 781: 100.00		KS6A6_HUMAN (1-740): 0: 771: 76.54
+	Hs
		270375 RFA1_HUMAN (1-616): 0: 781: 100.00		KS6A5_HUMAN (47-734): 0: 703: 40.86
+	Hs
		650467 RFA1_HUMAN (1-616): 0: 781: 100.00		AKT2_HUMAN (327-739): 1.82e-126: 387: 21.76
+	Hs
		650466 RFA1_HUMAN (1-616): 0: 781: 100.00		AKT1_HUMAN (327-739): 2.87e-125: 383: 21.02
+	Hs
		616673 RFA1_HUMAN (1-616): 0: 781: 100.00		KS6B1_HUMAN (397-727): 8.14e-116: 361: 25.50
+	Hs
		568552 RFA1_HUMAN (1-616): 0: 781: 100.00		KAPCA_HUMAN (409-714): 2.99e-117: 358: 28.84
+	Dm
		1097973 RFA1_DROME (1-614): 0: 619: 41.00		Q94533_DROME (420-732): 1.41e-99: 317: 28.49