HitPredict

Interactor 1: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Interactor 2: UFO (P30530)
Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene)
Gene: AXL

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.907

Property	Details
Experiments	18346204, 9178760, 35384245, 12470648
Identification Methods	affinity chromatography technology, enzymatic study, two hybrid, far western blotting, anti tag coimmunoprecipitation, coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0034446 - substrate adhesion-dependent cell spreading GO:0043066 - negative regulation of apoptotic process GO:0043548 - phosphatidylinositol 3-kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 894
+	Mm
		643079 P85A_MOUSE (1-724): 0: 592: 95.99		UFO_MOUSE (8-894): 0: 745: 88.29
+	Hs
		655220 P85A_HUMAN (1-724): 0: 596: 100.00		EPHA3_HUMAN (2-831): 0: 646: 19.34
+	Hs
		655285 P85A_HUMAN (1-724): 0: 596: 100.00		EPHA4_HUMAN (2-836): 0: 637: 19.40
+	Hs
		655284 P85A_HUMAN (1-724): 0: 596: 100.00		EPHA5_HUMAN (2-812): 0: 622: 20.39
+	Hs
		655380 P85A_HUMAN (1-724): 0: 596: 100.00		EPHA7_HUMAN (2-837): 0: 621: 19.50
+	Hs
		655222 P85A_HUMAN (1-724): 0: 596: 100.00		EPHB2_HUMAN (2-837): 0: 605: 19.58
+	Hs
		655219 P85A_HUMAN (1-724): 0: 596: 100.00		EPHA2_HUMAN (3-837): 0: 604: 19.66
+	Hs
		655221 P85A_HUMAN (1-724): 0: 596: 100.00		EPHA8_HUMAN (2-824): 0: 590: 19.20
+	Hs
		600513 P85A_HUMAN (1-724): 0: 596: 100.00		EPHA1_HUMAN (1-837): 0: 555: 20.58
+	Hs
		411306 P85A_HUMAN (1-724): 0: 596: 100.00		INSR_HUMAN (272-851): 1.65e-136: 443: 27.97
+	Mm
		546262 P85A_MOUSE (1-724): 0: 592: 95.99		INSR_MOUSE (232-851): 2.75e-135: 439: 26.37
+	Hs
		441439 P85A_HUMAN (1-724): 0: 596: 100.00		MET_HUMAN (536-799): 3.42e-66: 243: 45.90
+	Hs
		655325 P85A_HUMAN (1-724): 0: 596: 100.00		FAK1_HUMAN (527-851): 1.72e-56: 213: 36.83
+	Mm
		643057 P85A_MOUSE (1-724): 0: 592: 95.99		FAK1_MOUSE (527-889): 3.59e-57: 215: 34.95
+	Mm
		643062 P85A_MOUSE (1-724): 0: 592: 95.99		RET_MOUSE (501-834): 4.03e-56: 212: 36.01
+	Hs
		601463 P85A_HUMAN (1-724): 0: 596: 100.00		FGFR2_HUMAN (27-239): 5.42e-33: 139: 14.46
+	Hs
		609182 P85A_HUMAN (1-724): 0: 596: 100.00		FGFR3_HUMAN (2-135): 5.06e-15: 81.7: 14.29
+	Hs
		655328 P85A_HUMAN (1-724): 0: 596: 100.00		TYRO3_HUMAN (8-328): 1.16e-14: 80.5: 16.42
+	Hs
		507870 P85A_HUMAN (1-724): 0: 596: 100.00		FGFR1_HUMAN (10-149): 2.65e-12: 72.9: 15.69
+	Hs
		435546 P85A_HUMAN (1-724): 0: 596: 100.00		IGF1R_HUMAN (234-385): 4.65e-12: 72.4: 18.07