HitPredict

Interactor 1: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Interactor 2: FAK2 (Q14289)
Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)
Gene: PTK2B

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	15539082
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043066 - negative regulation of apoptotic process GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 1009
+	Hs
		655325 P85A_HUMAN (1-724): 0: 596: 100.00		FAK1_HUMAN (39-1000): 0: 846: 44.25
+	Hs
		337356 P85A_HUMAN (1-724): 0: 596: 100.00		ABL1_HUMAN (264-885): 2.55e-133: 432: 23.56
+	Hs
		69202 P85A_HUMAN (1-724): 0: 596: 100.00		A9UF07_HUMAN (264-885): 3.93e-127: 426: 23.56
+	Hs
		561382 P85A_HUMAN (1-724): 0: 596: 100.00		FER_HUMAN (93-684): 5.5e-134: 425: 24.72
+	Hs
		655377 P85A_HUMAN (1-724): 0: 596: 100.00		ERBB4_HUMAN (240-925): 9.44e-128: 421: 22.59
+	Hs
		655284 P85A_HUMAN (1-724): 0: 596: 100.00		EPHA5_HUMAN (202-712): 3.58e-129: 419: 26.15
+	Hs
		655254 P85A_HUMAN (1-724): 0: 596: 100.00		ABL2_HUMAN (222-877): 3.65e-126: 414: 22.85
+	Hs
		383629 P85A_HUMAN (1-724): 0: 596: 100.00		ERBB2_HUMAN (286-908): 2.13e-124: 411: 21.96
+	Hs
		411607 P85A_HUMAN (1-724): 0: 596: 100.00		LCK_HUMAN (208-694): 1.45e-123: 387: 27.18
+	Mm
		411918 P85A_MOUSE (1-724): 0: 592: 95.99		LCK_MOUSE (208-694): 4.72e-124: 389: 27.59
+	Hs
		655220 P85A_HUMAN (1-724): 0: 596: 100.00		EPHA3_HUMAN (380-701): 6.95e-116: 382: 33.13
+	Hs
		655219 P85A_HUMAN (1-724): 0: 596: 100.00		EPHA2_HUMAN (362-719): 1.23e-115: 381: 32.04
+	Hs
		522796 P85A_HUMAN (1-724): 0: 596: 100.00		SRC_HUMAN (288-695): 5.62e-117: 371: 27.74
+	Hs
		412033 P85A_HUMAN (1-724): 0: 596: 100.00		FYN_HUMAN (288-695): 1.25e-116: 370: 29.68
+	Hs
		433263 P85A_HUMAN (1-724): 0: 596: 100.00		YES_HUMAN (288-695): 1.7e-116: 370: 28.71
+	Hs
		442782 P85A_HUMAN (1-724): 0: 596: 100.00		HCK_HUMAN (286-694): 3.05e-116: 369: 30.10
+	Hs
		507870 P85A_HUMAN (1-724): 0: 596: 100.00		FGFR1_HUMAN (360-728): 4.75e-110: 362: 29.08
+	Hs
		655285 P85A_HUMAN (1-724): 0: 596: 100.00		EPHA4_HUMAN (388-709): 3.79e-108: 361: 35.89
+	Hs
		609182 P85A_HUMAN (1-724): 0: 596: 100.00		FGFR3_HUMAN (351-683): 4.17e-109: 359: 31.39
+	Hs
		655222 P85A_HUMAN (1-724): 0: 596: 100.00		EPHB2_HUMAN (390-679): 4.86e-56: 213: 38.33