HitPredict

Interactor 1: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Interactor 2: ERBB4 (Q15303)
Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]
Gene: ERBB4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22973453
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 1308
+	Hs
		601815 P85A_HUMAN (1-724): 0: 596: 100.00		ERBB3_HUMAN (1-1258): 0: 1094: 47.33
+	Hs
		383629 P85A_HUMAN (1-724): 0: 596: 100.00		ERBB2_HUMAN (25-1272): 0: 1090: 46.29
+	Mm
		643074 P85A_MOUSE (1-724): 0: 592: 95.99		ERBB2_MOUSE (6-1272): 0: 1082: 44.49
+	Hs
		337978 P85A_HUMAN (1-724): 0: 596: 100.00		EGFR_HUMAN (20-1286): 0: 1039: 48.70
+	Hs
		655366 P85A_HUMAN (1-724): 0: 596: 100.00		FAK2_HUMAN (676-1190): 1.28e-126: 418: 26.79
+	Hs
		337356 P85A_HUMAN (1-724): 0: 596: 100.00		ABL1_HUMAN (693-1305): 3.03e-121: 406: 25.00
+	Hs
		655219 P85A_HUMAN (1-724): 0: 596: 100.00		EPHA2_HUMAN (671-1010): 7.32e-119: 396: 35.41
+	Hs
		655222 P85A_HUMAN (1-724): 0: 596: 100.00		EPHB2_HUMAN (647-987): 4.64e-116: 390: 34.45
+	Mm
		936453 P70304_MOUSE (1-724): 0: 591: 95.86		EPHA2_MOUSE (688-1001): 4.69e-115: 386: 38.46
+	Hs
		129151 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		ABL1_HUMAN (693-1305): 3.03e-121: 406: 25.00
+	Hs
		655325 P85A_HUMAN (1-724): 0: 596: 100.00		FAK1_HUMAN (703-997): 6.55e-59: 223: 39.53
+	Mm
		643057 P85A_MOUSE (1-724): 0: 592: 95.99		FAK1_MOUSE (703-997): 3.71e-59: 224: 39.19
+	Hs
		655254 P85A_HUMAN (1-724): 0: 596: 100.00		ABL2_HUMAN (713-980): 1.37e-55: 214: 42.59
+	Hs
		655334 P85A_HUMAN (1-724): 0: 596: 100.00		ACK1_HUMAN (697-970): 1.51e-54: 209: 40.43
+	Hs
		655220 P85A_HUMAN (1-724): 0: 596: 100.00		EPHA3_HUMAN (705-987): 6.17e-54: 207: 39.10
+	Hs
		655259 P85A_HUMAN (1-724): 0: 596: 100.00		ZAP70_HUMAN (724-967): 1.42e-54: 204: 41.63
+	Hs
		411306 P85A_HUMAN (1-724): 0: 596: 100.00		INSR_HUMAN (353-660): 7.21e-32: 138: 19.05
+	Hs
		435546 P85A_HUMAN (1-724): 0: 596: 100.00		IGF1R_HUMAN (333-691): 3.78e-32: 138: 18.11
+	Mm
		546262 P85A_MOUSE (1-724): 0: 592: 95.99		INSR_MOUSE (353-660): 5.51e-32: 138: 19.05
+	Rn
		544879 P85A_RAT (1-724): 0: 580: 94.20		INSR_RAT (353-660): 1.09e-31: 137: 19.05