HitPredict

Interactor 1: PSA5 (P28066)
Proteasome subunit alpha type-5 (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome zeta chain)
Gene: PSMA5

Interactor 2: PSMA8 (Q8TAA3)
Proteasome subunit alpha-type 8 (Proteasome alpha 4 subunit) (Alpha4s) (Proteasome subunit alpha-type 7-like)
Gene: PSMA8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Proteasome~Proteasome, Proteasome~Proteasome_A_N, Proteasome_A_N~Proteasome_A_N
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0019773 - proteasome core complex, alpha-subunit complex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0070062 - extracellular exosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 241 Hs			1 256
+	Hs
		156230 PSA5_HUMAN (1-241): 1.49e-107: 311: 100.00		PSA7_HUMAN (5-238): 2.46e-101: 296: 82.91
+	Hs
		656149 PSA5_HUMAN (1-241): 1.49e-107: 311: 100.00		PSA5_HUMAN (3-240): 2.51e-91: 271: 36.74
+	Hs
		656189 PSA5_HUMAN (1-241): 1.49e-107: 311: 100.00		PSA6_HUMAN (2-243): 1.76e-91: 271: 29.27
+	Dm
		611647 PSA5_DROME (1-241): 1.3e-103: 301: 70.37		PSA71_DROME (1-237): 2.13e-94: 279: 69.20
+	Sc
		689186 PSA5_YEAST (1-241): 7.4e-95: 280: 60.49		PSA4_YEAST (3-240): 2.45e-102: 299: 54.77
+	Hs
		637325 PSA5_HUMAN (1-241): 1.49e-107: 311: 100.00		PSA1_HUMAN (3-249): 1.17e-89: 267: 31.08
+	Ss
		94704 F2Z5K2_PIG (1-241): 1.49e-107: 311: 100.00		F2Z5L7_PIG (3-249): 1.17e-89: 267: 31.08
+	Sp
		1013784 PSA5_SCHPO (1-240): 1.27e-105: 307: 61.41		PSA4_SCHPO (3-255): 8.15e-91: 270: 53.33
+	Hs
		638067 PSA5_HUMAN (1-241): 1.49e-107: 311: 100.00		PSA4_HUMAN (1-237): 2.99e-89: 266: 34.84
+	Dm
		611631 PSA2_DROME (3-241): 1.55e-99: 291: 31.38		PSA71_DROME (1-237): 2.13e-94: 279: 69.20
+	Hs
		156224 PSA2_HUMAN (3-241): 3.37e-89: 265: 30.96		PSA7_HUMAN (5-238): 2.46e-101: 296: 82.91
+	Ce
		1278560 PSA5_CAEEL (1-241): 1.3e-93: 276: 59.84		PSA7_CAEEL (3-240): 1.92e-93: 277: 57.26
+	Ss
		94582 F1SBA5_PIG (6-235): 1.55e-90: 268: 38.20		F2Z5L7_PIG (3-249): 1.17e-89: 267: 31.08
+	Hs
		637316 PSA2_HUMAN (3-241): 3.37e-89: 265: 30.96		PSA1_HUMAN (3-249): 1.17e-89: 267: 31.08
+	Hs
		637626 PSA2_HUMAN (3-241): 3.37e-89: 265: 30.96		PSA4_HUMAN (1-237): 2.99e-89: 266: 34.84
+	Hs
		637631 PSA5_HUMAN (1-241): 1.49e-107: 311: 100.00		PSA2_HUMAN (1-240): 6.58e-46: 155: 39.51
+	Dm
		771303 PSA5_DROME (1-241): 1.3e-103: 301: 70.37		PSA2_DROME (4-222): 1.8e-47: 159: 40.27
+	Hv
		1358195 PSA1_HALVD (5-240): 6.5e-93: 275: 40.51		PSA1_HALVD (5-210): 1.26e-45: 154: 42.72
+	Hs
		637624 PSA2_HUMAN (3-241): 3.37e-89: 265: 30.96		PSA2_HUMAN (1-240): 6.58e-46: 155: 39.51