Protein: LNX2
Ligand of Numb protein X 2 (Numb-binding protein 2) (PDZ domain-containing RING finger protein 1)

Gene: LNX2
Organism: Homo sapiens
Interactions: 112
UniProt ID: Q8N448

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005886 - plasma membrane
GO:0008270 - zinc ion binding
GO:0030165 - PDZ domain binding
GO:0030182 - neuron differentiation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1325736

LNX2
Ligand of Numb protein X 2

2

18

Small-scale

0.833

High

889307

NUMB
Protein numb homolog

3

18

Small-scale

0.828

High

855684

CRK
Adapter molecule crk

1

12

High-throughput

0.723

High

970771

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.723

High

1325740

RN138
E3 ubiquitin-protein ligase RNF138

1

19

High-throughput

0.698

High

1325762

UBE2T
Ubiquitin-conjugating enzyme E2 T

1

5

High-throughput

0.698

High

853822

MK09
Mitogen-activated protein kinase 9

3

14

High-throughput

0.658

High

1287194

PEG10
Retrotransposon-derived protein PEG10

3

1

High-throughput

0.658

High

1325741

MYLIP
E3 ubiquitin-protein ligase MYLIP

3

16

High-throughput

0.658

High

1325747

OPTN
Optineurin

3

14

High-throughput

0.658

High

443877

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

3

5

High-throughput

0.653

High

1237945

LRC8E
Volume-regulated anion channel subunit LRRC8E

3

13

High-throughput

0.653

High

1325765

RAB6B
Ras-related protein Rab-6B

1

8

High-throughput

0.647

High

982243

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

4

Small-scale

0.647

High

1325749

PTCD3
Small ribosomal subunit protein mS39

3

0

High-throughput

0.630

High

993653

UBC9
SUMO-conjugating enzyme UBC9

1

5

High-throughput

0.625

High

1325758

UBE2Z
Ubiquitin-conjugating enzyme E2 Z

1

7

High-throughput

0.625

High

1119755

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

1

18

High-throughput

0.621

High

1251876

PZRN4
PDZ domain-containing RING finger protein 4

1

20

Small-scale

0.621

High

1325738

LNX1
E3 ubiquitin-protein ligase LNX

1

19

Small-scale

0.621

High

1325776

PZRN3
E3 ubiquitin-protein ligase PDZRN3

1

18

Small-scale

0.621

High

1147375

EPHA7
Ephrin type-A receptor 7

1

20

Small-scale

0.618

High

1097103

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

3

10

High-throughput

0.601

High

1325752

SCLY
Selenocysteine lyase

3

1

High-throughput

0.601

High

1325773

IP6K2
Inositol hexakisphosphate kinase 2

3

1

High-throughput

0.601

High

457554

TBB5
Tubulin beta chain

3

9

High-throughput

0.596

High

1051496

SRS11
Serine/arginine-rich splicing factor 11

3

4

High-throughput

0.596

High

1325759

PAAT
ATPase PAAT

3

1

High-throughput

0.596

High

378906

CD8A
T-cell surface glycoprotein CD8 alpha chain

1

1

Small-scale

0.573

High

292850

GRAP2
GRB2-related adapter protein 2

1

20

High-throughput

0.560

High

699804

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

17

High-throughput

0.560

High

987771

GRB2
Growth factor receptor-bound protein 2

1

19

High-throughput

0.560

High

1093877

TRAF1
TNF receptor-associated factor 1

1

11

High-throughput

0.560

High

1116534

FHL3
Four and a half LIM domains protein 3

1

7

High-throughput

0.560

High

1290541

ZN410
Zinc finger protein 410

1

4

High-throughput

0.560

High

1325744

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

1

High-throughput

0.560

High

1325757

SCNM1
Sodium channel modifier 1

1

1

High-throughput

0.560

High

1325761

PARVG
Gamma-parvin

1

15

High-throughput

0.560

High

1325771

ZN581
Zinc finger protein 581

1

6

High-throughput

0.560

High

1325777

ZN148
Zinc finger protein 148

1

4

High-throughput

0.560

High

857503

NOTC1
Neurogenic locus notch homolog protein 1

1

11

High-throughput

0.541

High

1325769

RNF12
E3 ubiquitin-protein ligase RLIM

1

1

High-throughput

0.541

High

1325779

NEMO
NF-kappa-B essential modulator

1

4

High-throughput

0.536

High

361298

SODC
Superoxide dismutase [Cu-Zn]

1

2

High-throughput

0.515

High

788961

TGFR2
TGF-beta receptor type-2

1

3

High-throughput

0.515

High

791528

SYUA
Alpha-synuclein

1

6

High-throughput

0.515

High

1279630

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

14

High-throughput

0.515

High

49328

SHOT1
Shootin-1

1

1

Small-scale

0.512

High

216272

PPIH
Peptidyl-prolyl cis-trans isomerase H

1

5

High-throughput

0.512

High

300191

GLRX3
Glutaredoxin-3

1

5

High-throughput

0.512

High

325387

INMT
Indolethylamine N-methyltransferase

1

1

High-throughput

0.512

High

349340

NUD14
Uridine diphosphate glucose pyrophosphatase NUDT14

1

1

High-throughput

0.512

High

549195

CDK4
Cyclin-dependent kinase 4

1

2

High-throughput

0.512

High

589151

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.512

High

667933

CDK2
Cyclin-dependent kinase 2

1

4

High-throughput

0.512

High

730764

1433S
14-3-3 protein sigma

1

20

High-throughput

0.512

High

756266

MCM7
DNA replication licensing factor MCM7

1

1

High-throughput

0.512

High

842978

CDN2C
Cyclin-dependent kinase 4 inhibitor C

1

20

High-throughput

0.512

High

882029

TCPG
T-complex protein 1 subunit gamma

1

1

High-throughput

0.512

High

940454

TCL1A
T-cell leukemia/lymphoma protein 1A

1

2

High-throughput

0.512

High

945653

CABP4
Calcium-binding protein 4

1

1

High-throughput

0.512

High

1133352

NC2A
Dr1-associated corepressor

1

1

High-throughput

0.512

High

1325739

PPL13
Placental protein 13-like

1

3

High-throughput

0.512

High

1325742

PSMF1
Proteasome inhibitor PI31 subunit

1

1

High-throughput

0.512

High

1325745

TIFA
TRAF-interacting protein with FHA domain-containing protein A

1

1

High-throughput

0.512

High

1325751

MR1L1
MORF4 family-associated protein 1-like 1

1

2

High-throughput

0.512

High

1325760

ROP1A
Ropporin-1A

1

1

High-throughput

0.512

High

1325763

SHLB2
Endophilin-B2

1

9

High-throughput

0.512

High

1325772

MLX
Max-like protein X

1

6

High-throughput

0.512

High

1325774

NAGK
N-acetyl-D-glucosamine kinase

1

2

High-throughput

0.512

High

1325778

PPIL1
Peptidyl-prolyl cis-trans isomerase-like 1

1

5

High-throughput

0.512

High

1090783

TRAF2
TNF receptor-associated factor 2

1

20

High-throughput

0.508

High

1312635

MSRB3
Methionine-R-sulfoxide reductase B3

1

1

High-throughput

0.508

High

1325775

CXD2
Gap junction delta-2 protein

1

12

Small-scale

0.501

High

1004126

CXAR
Coxsackievirus and adenovirus receptor

1

20

Small-scale

0.481

High

1040851

MECOM
Histone-lysine N-methyltransferase MECOM

1

5

High-throughput

0.481

High

1325737

MDGA1
MAM domain-containing glycosylphosphatidylinositol anchor protein 1

1

18

Small-scale

0.481

High

318091

PKHG5
Pleckstrin homology domain-containing family G member 5

1

20

Small-scale

0.479

High

603307

KPCA
Protein kinase C alpha type

1

18

Small-scale

0.479

High

1226629

E4F1
Transcription factor E4F1

1

4

Small-scale

0.479

High

1325754

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

19

Small-scale

0.479

High

246038

KIF1B
Kinesin-like protein KIF1B

1

20

High-throughput

0.470

High

843760

HD
Huntingtin

1

4

High-throughput

0.470

High

853343

CBX5
Chromobox protein homolog 5

1

4

High-throughput

0.470

High

927412

ATX1
Ataxin-1

1

1

High-throughput

0.470

High

1096095

TADBP
TAR DNA-binding protein 43

1

2

High-throughput

0.470

High

399597

VTNC
Vitronectin

1

2

High-throughput

0.464

High

1325743

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

18

High-throughput

0.464

High

129769

CBX4
E3 SUMO-protein ligase CBX4

1

4

Small-scale

0.439

High

288463

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

3

High-throughput

0.439

High

1325766

IGSF5
Immunoglobulin superfamily member 5

1

4

Small-scale

0.439

High

1325767

PKDRE
Polycystin family receptor for egg jelly

1

8

Small-scale

0.439

High

1325764

LATS2
Serine/threonine-protein kinase LATS2

1

20

High-throughput

0.437

High

1325768

KLH11
Kelch-like protein 11

1

10

Small-scale

0.437

High

1308117

AT2L2
5-phosphohydroxy-L-lysine phospho-lyase

3

0

High-throughput

0.340

High

1325748

NMD3
60S ribosomal export protein NMD3

3

0

High-throughput

0.340

High

180338

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.292

High

185215

FANCG
Fanconi anemia group G protein

1

0

High-throughput

0.292

High

665274

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

0

High-throughput

0.292

High

1153066

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

0

High-throughput

0.292

High

1157405

PSMD5
26S proteasome non-ATPase regulatory subunit 5

1

0

High-throughput

0.292

High

1325746

EAF2
ELL-associated factor 2

1

0

High-throughput

0.292

High

1325750

NTAQ1
Protein N-terminal glutamine amidohydrolase

1

0

High-throughput

0.292

High

1325756

YJU2
Splicing factor YJU2

1

0

High-throughput

0.292

High

1325770

TBCD7
TBC1 domain family member 7

1

0

High-throughput

0.292

High

1086633

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

High-throughput

0.282

High

301558

WFS1
Wolframin

1

0

High-throughput

0.268

Low

415713

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.268

Low

1248472

SHSA2
Protein shisa-2 homolog

1

0

Small-scale

0.251

Low

1325753

SPF45
Splicing factor 45

1

0

High-throughput

0.251

Low

1325755

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025