HitPredict

Interactor 1: MSX1 (P28360)
Homeobox protein MSX-1 (Homeobox protein Hox-7) (Msh homeobox 1-like protein)
Gene: MSX1

Interactor 2: TLE2 (Q04725)
Transducin-like enhancer protein 2 (Enhancer of split groucho-like protein 2) (ESG2)
Gene: TLE2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	20211142
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005667 - transcription regulator complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 303 Hs			1 743
+	Mm
		526710 MSX1_MOUSE (1-303): 1.8e-46: 160: 93.73		TLE4_MOUSE (1-743): 1.35e-176: 526: 65.93
+	Hs
		980714 BARH1_HUMAN (57-287): 2.07e-32: 123: 26.50		TLE2_HUMAN (1-743): 0: 552: 100.00
+	Hs
		679098 TLX1_HUMAN (89-272): 7.62e-40: 143: 32.09		TLE4_HUMAN (1-743): 3.3e-176: 525: 65.93
+	Hs
		679096 TLX1_HUMAN (89-272): 7.62e-40: 143: 32.09		TLE1_HUMAN (1-743): 2.32e-174: 520: 65.46
+	Hs
		829830 HXA1_HUMAN (2-245): 5.06e-33: 125: 25.82		TLE1_HUMAN (1-743): 2.32e-174: 520: 65.46
+	Hs
		980644 BARH1_HUMAN (57-287): 2.07e-32: 123: 26.50		TLE1_HUMAN (1-743): 2.32e-174: 520: 65.46
+	Hs
		679097 TLX1_HUMAN (89-272): 7.62e-40: 143: 32.09		TLE3_HUMAN (1-743): 2.94e-166: 499: 63.91
+	Ce
		137685 HM30_CAEEL (123-288): 4.73e-35: 128: 28.57		UNC37_CAEEL (17-743): 8.34e-127: 392: 35.01
+	Ce
		137668 HM01_CAEEL (173-279): 5.81e-36: 127: 40.00		UNC37_CAEEL (17-743): 8.34e-127: 392: 35.01
+	Ce
		137665 UNC4_CAEEL (110-255): 3.96e-32: 121: 21.23		UNC37_CAEEL (17-743): 8.34e-127: 392: 35.01
+	Ce
		137664 HM19_CAEEL (167-246): 2.61e-32: 120: 40.00		UNC37_CAEEL (17-743): 8.34e-127: 392: 35.01
+	Ce
		137669 HM09_CAEEL (112-249): 1.63e-32: 119: 23.91		UNC37_CAEEL (17-743): 8.34e-127: 392: 35.01
+	Mm
		526708 MSX1_MOUSE (1-303): 1.8e-46: 160: 93.73		TLE5_MOUSE (1-185): 2.11e-91: 285: 62.37
+	Hs
		679101 TLX1_HUMAN (89-272): 7.62e-40: 143: 32.09		TLE5_HUMAN (1-185): 8.53e-92: 286: 62.89
+	Hs
		829834 HXA1_HUMAN (2-245): 5.06e-33: 125: 25.82		TLE5_HUMAN (1-185): 8.53e-92: 286: 62.89
+	Hs
		993568 PITX2_HUMAN (126-294): 1.37e-32: 124: 24.43		TLE5_HUMAN (1-185): 8.53e-92: 286: 62.89
+	Hs
		245566 TLX1_HUMAN (89-272): 7.62e-40: 143: 32.09		TBL1X_HUMAN (542-742): 1.23e-45: 174: 15.60
+	Mm
		192307 ALX4_MOUSE (5-303): 3.85e-34: 130: 16.17		TLE6_MOUSE (444-743): 4.72e-48: 181: 34.31
+	Mm
		446933 HXD3_MOUSE (1-301): 1.35e-32: 126: 21.61		TLE6_MOUSE (444-743): 4.72e-48: 181: 34.31
+	Hs
		903461 PITX2_HUMAN (126-294): 1.37e-32: 124: 24.43		WDR5_HUMAN (628-742): 1.63e-35: 139: 21.37