HitPredict

Interactor 1: MK01 (P28482)
Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
Gene: MAPK1

Interactor 2: DUS6 (Q16828)
Dual specificity protein phosphatase 6 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST1) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3)
Gene: DUSP6

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.975

Property	Details
Experiments	25515236, 27880917, 27432908, 28675297, 31980649, 9535927, 9596579, 26050649, 34857952, unassigned2173, 18060821, 12840032
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	DSPc~Pkinase, Pkinase~Rhodanese
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070371 - ERK1 and ERK2 cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 360 Hs			1 381
+	Rn
		926496 MK01_RAT (10-360): 4.96e-158: 449: 99.72		DUS6_RAT (1-381): 1.89e-148: 426: 98.69
+	Mm
		926439 MK01_MOUSE (10-360): 4.96e-158: 449: 99.72		DUS6_MOUSE (1-381): 4.99e-147: 422: 98.16
+	Hs
		658962 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS7_HUMAN (18-381): 2.8e-133: 389: 70.30
+	Hs
		658903 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS2_HUMAN (11-347): 6.86e-102: 305: 33.43
+	Hs
		658798 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS1_HUMAN (23-373): 1.17e-99: 302: 32.77
+	Hs
		659034 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS9_HUMAN (15-375): 2.37e-99: 301: 51.45
+	Hs
		659043 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS16_HUMAN (23-376): 8.48e-96: 301: 31.27
+	Mm
		926403 MK01_MOUSE (10-360): 4.96e-158: 449: 99.72		DUS2_MOUSE (11-347): 1.85e-98: 297: 34.02
+	Hs
		647553 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		DUS2_HUMAN (11-347): 6.86e-102: 305: 33.43
+	Hs
		659102 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS10_HUMAN (2-349): 4.7e-96: 296: 33.43
+	Hs
		647475 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		DUS1_HUMAN (23-373): 1.17e-99: 302: 32.77
+	Hs
		658919 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS4_HUMAN (29-374): 6.65e-96: 293: 33.05
+	Hs
		658960 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS5_HUMAN (26-372): 4.56e-94: 288: 29.55
+	Hs
		647563 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		DUS4_HUMAN (29-374): 6.65e-96: 293: 33.05
+	Hs
		658923 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS8_HUMAN (23-357): 2.13e-89: 283: 32.05
+	Hs
		659008 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		STYX_HUMAN (187-375): 1.18e-58: 191: 26.80
+	Hs
		659006 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS19_HUMAN (210-345): 2.77e-53: 177: 37.50
+	Hs
		658858 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS3_HUMAN (194-354): 5.11e-53: 175: 31.36
+	Hs
		647521 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		DUS3_HUMAN (194-354): 5.11e-53: 175: 31.36
+	Mm
		926438 MK01_MOUSE (10-360): 4.96e-158: 449: 99.72		DUS3_MOUSE (194-340): 3.2e-16: 77.8: 35.67