Protein: PTPRG
Receptor-type tyrosine-protein phosphatase gamma (Protein-tyrosine phosphatase gamma) (R-PTP-gamma) (EC 3.1.3.48)

Gene: PTPRG
Organism: Homo sapiens
Interactions: 122
UniProt ID: P23470

Gene Ontology (top 5):
GO:0004725 - protein tyrosine phosphatase activity
GO:0005001 - transmembrane receptor protein tyrosine phosphatase activity
GO:0005886 - plasma membrane
GO:0007165 - signal transduction
GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

141987

FCN1
Ficolin-1

3

4

High-throughput

0.861

High

658989

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

2

19

Small-scale

0.815

High

659061

DUS22
Dual specificity protein phosphatase 22

2

1

High-throughput

0.811

High

659039

SPA12
Serpin A12

3

0

High-throughput

0.811

High

659010

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

362781

EGFR
Epidermal growth factor receptor

2

20

Small-scale

0.743

High

659016

PKD1
Polycystin-1

1

4

Small-scale

0.713

High

484058

PGFRB
Platelet-derived growth factor receptor beta

2

18

High-throughput

0.712

High

616720

SDC1
Syndecan-1

2

3

High-throughput

0.628

High

659067

PCDGK
Protocadherin gamma-C3

2

15

High-throughput

0.628

High

659014

DLG4
Disks large homolog 4

1

7

Small-scale

0.621

High

340985

DIRA3
GTP-binding protein Di-Ras3

1

3

High-throughput

0.618

High

373776

RASN
GTPase NRas

1

15

High-throughput

0.618

High

375179

RASK
GTPase KRas

1

17

High-throughput

0.618

High

463335

LYN
Tyrosine-protein kinase Lyn

1

20

High-throughput

0.618

High

601175

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

614650

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

17

Small-scale

0.618

High

658805

PTPRB
Receptor-type tyrosine-protein phosphatase beta

1

20

High-throughput

0.618

High

658994

MERL
Merlin

1

6

High-throughput

0.618

High

659000

MUC18
Cell surface glycoprotein MUC18

1

13

High-throughput

0.618

High

659004

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

659006

RAB2A
Ras-related protein Rab-2A

1

2

High-throughput

0.618

High

659007

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

659008

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.618

High

659013

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

659026

RAB35
Ras-related protein Rab-35

1

6

High-throughput

0.618

High

659027

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

659036

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

659043

PARD3
Partitioning defective 3 homolog

1

8

High-throughput

0.618

High

659047

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.618

High

659057

DUS26
Dual specificity protein phosphatase 26

1

1

High-throughput

0.618

High

659060

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

659070

MRCKB
Serine/threonine-protein kinase MRCK beta

1

2

High-throughput

0.618

High

127279

LEG8
Galectin-8

3

20

High-throughput

0.609

High

480706

LEG1
Galectin-1

2

20

High-throughput

0.601

High

193501

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

5

High-throughput

0.575

High

410624

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.575

High

411369

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.575

High

439642

INSR
Insulin receptor

1

20

High-throughput

0.575

High

439951

LCK
Tyrosine-protein kinase Lck

1

20

High-throughput

0.575

High

471989

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.575

High

619206

EPOR
Erythropoietin receptor

1

20

High-throughput

0.575

High

651153

CBL
E3 ubiquitin-protein ligase CBL

1

8

High-throughput

0.575

High

658990

MK03
Mitogen-activated protein kinase 3

1

11

High-throughput

0.575

High

658995

TIE1
Tyrosine-protein kinase receptor Tie-1

1

20

High-throughput

0.575

High

658997

CSK
Tyrosine-protein kinase CSK

1

20

High-throughput

0.575

High

658998

TEC
Tyrosine-protein kinase Tec

1

20

High-throughput

0.575

High

659017

TIE2
Angiopoietin-1 receptor

1

18

High-throughput

0.575

High

659066

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.575

High

659032

CXB7
Gap junction beta-7 protein

2

1

High-throughput

0.574

High

658993

CTNB1
Catenin beta-1

2

20

Small-scale

0.571

High

659035

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.553

High

659045

CSKI2
Caskin-2

1

7

High-throughput

0.553

High

659069

FARP1
FERM, ARHGEF and pleckstrin domain-containing protein 1

1

4

High-throughput

0.553

High

659063

FBX2
F-box only protein 2

2

9

High-throughput

0.549

High

609577

LEG3
Galectin-3

1

20

High-throughput

0.536

High

659046

NICA
Nicastrin

1

1

High-throughput

0.536

High

659058

DUS23
Dual specificity protein phosphatase 23

1

4

High-throughput

0.536

High

474483

VIME
Vimentin

1

1

High-throughput

0.515

High

125238

LEG9
Galectin-9

1

20

High-throughput

0.489

High

488275

CSF3
Granulocyte colony-stimulating factor

1

1

High-throughput

0.489

High

659021

SG2A2
Mammaglobin-A

1

1

High-throughput

0.489

High

659034

ZN517
Zinc finger protein 517

1

3

High-throughput

0.489

High

659050

CERS2
Ceramide synthase 2

1

3

High-throughput

0.489

High

659024

PKD2
Polycystin-2

1

9

Small-scale

0.481

High

472273

CFAH
Complement factor H

1

5

Small-scale

0.479

High

540313

LAMP1
Lysosome-associated membrane glycoprotein 1

1

3

High-throughput

0.479

High

555876

CADH1
Cadherin-1

1

20

Small-scale

0.479

High

561898

LAMP2
Lysosome-associated membrane glycoprotein 2

1

3

High-throughput

0.479

High

580597

AMPN
Aminopeptidase N

1

1

High-throughput

0.479

High

603835

CXA1
Gap junction alpha-1 protein

1

1

High-throughput

0.479

High

658991

DPP4
Dipeptidyl peptidase 4

1

2

High-throughput

0.479

High

658996

ADDB
Beta-adducin

1

1

High-throughput

0.479

High

659003

LMAN1
Protein ERGIC-53

1

2

High-throughput

0.479

High

659009

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.479

High

659012

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.479

High

659018

CAV1
Caveolin-1

1

1

High-throughput

0.479

High

659019

FCHO2
F-BAR domain only protein 2

1

6

High-throughput

0.479

High

659031

LTOR1
Ragulator complex protein LAMTOR1

1

2

High-throughput

0.479

High

659037

GRIN1
G protein-regulated inducer of neurite outgrowth 1

1

4

High-throughput

0.479

High

659038

TM11B
Transmembrane protease serine 11B

1

6

High-throughput

0.479

High

659048

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.479

High

659056

NIBA2
Protein Niban 2

1

1

High-throughput

0.479

High

659065

S39AA
Zinc transporter ZIP10

1

4

High-throughput

0.479

High

659068

LAMP3
Lysosome-associated membrane glycoprotein 3

1

3

High-throughput

0.479

High

212932

HS12A
Heat shock 70 kDa protein 12A

1

0

High-throughput

0.458

High

292427

PALM
Paralemmin-1

1

0

High-throughput

0.458

High

658992

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.458

High

659005

ICLN
Methylosome subunit pICln

1

0

High-throughput

0.458

High

659028

OCLN
Occludin

1

0

High-throughput

0.458

High

659064

CDV3
Protein CDV3 homolog

1

0

High-throughput

0.458

High

254813

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

5

High-throughput

0.445

High

618216

CADH2
Cadherin-2

1

20

High-throughput

0.445

High

658999

WASP
Actin nucleation-promoting factor WAS

1

6

High-throughput

0.445

High

659001

NSF
Vesicle-fusing ATPase

1

12

High-throughput

0.445

High

659002

PAXI
Paxillin

1

10

High-throughput

0.445

High

659020

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

9

High-throughput

0.445

High

659022

GAB1
GRB2-associated-binding protein 1

1

5

High-throughput

0.445

High

659025

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

7

High-throughput

0.445

High

338289

SC24A
Protein transport protein Sec24A

1

1

High-throughput

0.437

High

659055

CEP89
Centrosomal protein of 89 kDa

1

3

High-throughput

0.437

High

659062

PSD3
PH and SEC7 domain-containing protein 3

1

2

High-throughput

0.437

High

659015

DLK1
Protein delta homolog 1

1

9

High-throughput

0.407

High

659051

MF14A
Hippocampus abundant transcript 1 protein

1

6

High-throughput

0.407

High

659059

ZDH11
Palmitoyltransferase ZDHHC11

1

4

High-throughput

0.407

High

659041

T185A
Transmembrane protein 185A

3

0

High-throughput

0.347

High

659052

UIF
UAP56-interacting factor

3

0

High-throughput

0.347

High

659054

CCNL2
Cyclin-L2

3

0

High-throughput

0.347

High

340436

DUS4L
tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like

2

0

High-throughput

0.328

High

659023

MED21
Mediator of RNA polymerase II transcription subunit 21

2

0

High-throughput

0.328

High

659049

ISG20
Interferon-stimulated gene 20 kDa protein

2

0

High-throughput

0.328

High

155286

CDKA1
Cyclin-dependent kinase 2-associated protein 1

1

0

High-throughput

0.279

Low

659029

PCGF3
Polycomb group RING finger protein 3

1

0

High-throughput

0.279

Low

659030

ARM12
Armadillo repeat-containing protein 12

1

0

High-throughput

0.279

Low

659040

ACBD7
Acyl-CoA-binding domain-containing protein 7

1

0

High-throughput

0.279

Low

659042

NPB
Neuropeptide B

1

0

High-throughput

0.279

Low

659044

D104A
Beta-defensin 104

1

0

High-throughput

0.279

Low

659053

CLCC1
Chloride channel CLIC-like protein 1

1

0

High-throughput

0.279

Low

659071

IR3IP
Immediate early response 3-interacting protein 1

1

0

High-throughput

0.279

Low

659033

PACS1
Phosphofurin acidic cluster sorting protein 1

1

0

High-throughput

0.269

Low

659011

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025