HitPredict

Interactor 1: RBL1 (P28749)
Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1)
Gene: RBL1

Interactor 2: E2F5 (Q15329)
Transcription factor E2F5 (E2F-5)
Gene: E2F5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	7760804
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	E2F_CC-MB~Rb_C
Common GO terms	GO:0000785 - chromatin GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1068 Hs			1 346
+	Hs
		660138 RBL1_HUMAN (1-1068): 0: 1528: 100.00		E2F2_HUMAN (10-340): 1.51e-101: 307: 35.00
+	Hs
		135214 RBL1_HUMAN (1-1068): 0: 1528: 100.00		E2F3_HUMAN (8-340): 3.77e-100: 305: 32.64
+	Hs
		660118 RBL1_HUMAN (1-1068): 0: 1528: 100.00		E2F1_HUMAN (10-340): 1.7e-95: 292: 29.54
+	Hs
		997123 RBL2_HUMAN (19-1068): 0: 1356: 50.32		E2F5_HUMAN (1-346): 6.29e-137: 394: 100.00
+	Hs
		963598 RBL2_HUMAN (19-1068): 0: 1356: 50.32		E2F1_HUMAN (10-340): 1.7e-95: 292: 29.54
+	Hs
		660145 RBL1_HUMAN (1-1068): 0: 1528: 100.00		E2F4_HUMAN (268-345): 2.71e-13: 72.2: 43.37
+	Mm
		1145491 RBL1_MOUSE (1-1068): 0: 1473: 90.45		E2F4_MOUSE (268-344): 1.61e-12: 69.9: 42.68
+	Hs
		997125 RBL2_HUMAN (19-1068): 0: 1356: 50.32		E2F4_HUMAN (268-345): 2.71e-13: 72.2: 43.37
+	Hs
		414295 RB_HUMAN (735-1046): 2.21e-85: 298: 28.88		E2F5_HUMAN (1-346): 6.29e-137: 394: 100.00
+	Mm
		192503 RB_MOUSE (718-1046): 4.9e-86: 300: 28.32		E2F3_MOUSE (8-340): 2.02e-100: 305: 32.64
+	Hs
		414284 RB_HUMAN (735-1046): 2.21e-85: 298: 28.88		E2F2_HUMAN (10-340): 1.51e-101: 307: 35.00
+	Hs
		135199 RB_HUMAN (735-1046): 2.21e-85: 298: 28.88		E2F3_HUMAN (8-340): 3.77e-100: 305: 32.64
+	Mm
		527140 RB_MOUSE (718-1046): 4.9e-86: 300: 28.32		E2F2_MOUSE (10-340): 2.42e-96: 294: 33.79
+	Hs
		414250 RB_HUMAN (735-1046): 2.21e-85: 298: 28.88		E2F1_HUMAN (10-340): 1.7e-95: 292: 29.54
+	Mm
		527156 RB_MOUSE (718-1046): 4.9e-86: 300: 28.32		E2F1_MOUSE (32-340): 1.02e-93: 287: 34.25
+	Rn
		140344 RB_RAT (735-1046): 1.14e-84: 296: 28.27		E2F1_RAT (32-340): 1.79e-93: 287: 33.74
+	Hs
		265585 RB_HUMAN (735-1046): 2.21e-85: 298: 28.88		E2F6_HUMAN (50-258): 9.84e-70: 220: 36.02
+	Dm
		284513 RBF_DROME (779-1028): 7.56e-72: 258: 31.47		E2F2_DROME (2-342): 1.35e-79: 249: 29.70
+	Hs
		414299 RB_HUMAN (735-1046): 2.21e-85: 298: 28.88		E2F4_HUMAN (268-345): 2.71e-13: 72.2: 43.37
+	Mm
		527164 RB_MOUSE (718-1046): 4.9e-86: 300: 28.32		E2F4_MOUSE (268-344): 1.61e-12: 69.9: 42.68