Protein: COF2
Cofilin-2 (Cofilin, muscle isoform)

Gene: COF2, CFL2
Organism: Homo sapiens
Interactions: 96
UniProt ID: Q9Y281

Gene Ontology (top 5):
GO:0005615 - extracellular space
GO:0005737 - cytoplasm
GO:0007519 - skeletal muscle tissue development
GO:0015629 - actin cytoskeleton
GO:0016363 - nuclear matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

953195

ACTB
Actin, cytoplasmic 1

8

20

High-throughput

0.975

High

993390

ACTG
Actin, cytoplasmic 2

7

20

High-throughput

0.973

High

660192

COF1
Cofilin-1

7

12

High-throughput

0.959

High

955868

DEST
Destrin

3

12

High-throughput

0.839

High

867529

CAPZB
F-actin-capping protein subunit beta

1

4

High-throughput

0.691

High

1160807

DREB
Drebrin

1

3

High-throughput

0.691

High

995907

ACTC
Actin, alpha cardiac muscle 1

1

20

High-throughput

0.665

High

1490565

COF2
Cofilin-2

1

12

High-throughput

0.621

High

1365623

MY18A
Unconventional myosin-XVIIIa

2

8

High-throughput

0.611

High

956547

RAB2A
Ras-related protein Rab-2A

2

1

High-throughput

0.606

High

1420567

TRIM7
E3 ubiquitin-protein ligase TRIM7

2

3

High-throughput

0.606

High

1450189

POTE1
Protection of telomeres protein 1

3

3

High-throughput

0.597

High

1447461

ANLN
Anillin

2

3

High-throughput

0.584

High

1005256

RNF4
E3 ubiquitin-protein ligase RNF4

2

0

High-throughput

0.580

High

1154480

STK11
Serine/threonine-protein kinase STK11

1

5

High-throughput

0.541

High

123879

MYO1C
Unconventional myosin-Ic

1

11

High-throughput

0.536

High

530613

TAU
Microtubule-associated protein tau

1

7

High-throughput

0.536

High

637796

FLNA
Filamin-A

1

4

High-throughput

0.536

High

773089

MYH9
Myosin-9

1

4

High-throughput

0.536

High

863036

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

5

High-throughput

0.536

High

866874

CAZA2
F-actin-capping protein subunit alpha-2

1

5

High-throughput

0.536

High

920535

DAPK1
Death-associated protein kinase 1

1

6

High-throughput

0.536

High

968491

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

4

High-throughput

0.536

High

1124759

SRC8
Src substrate cortactin

1

4

High-throughput

0.536

High

1325469

SYNPO
Synaptopodin

1

4

High-throughput

0.536

High

1352234

TBCK
TBC domain-containing protein kinase-like protein

1

4

High-throughput

0.536

High

1392701

MYO19
Unconventional myosin-XIX

1

7

High-throughput

0.536

High

1459755

LIMA1
LIM domain and actin-binding protein 1

1

4

High-throughput

0.536

High

693141

DPP4
Dipeptidyl peptidase 4

1

2

High-throughput

0.515

High

1369720

KLK6
Kallikrein-6

1

2

High-throughput

0.515

High

1438901

MOV10
Helicase MOV-10

1

0

High-throughput

0.513

High

1460256

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.513

High

1490567

MB212
Protein mab-21-like 2

1

0

High-throughput

0.513

High

1124089

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.493

High

1447302

PRDM7
Histone-lysine N-methyltransferase PRDM7

1

1

High-throughput

0.489

High

818812

CAP2
Adenylyl cyclase-associated protein 2

1

9

High-throughput

0.481

High

993819

UBC9
SUMO-conjugating enzyme UBC9

1

2

High-throughput

0.481

High

895840

CSRP3
Cysteine and glycine-rich protein 3

1

0

Small-scale

0.480

High

212698

DAPK3
Death-associated protein kinase 3

1

7

High-throughput

0.479

High

223434

PRC1
Protein regulator of cytokinesis 1

1

7

High-throughput

0.479

High

243323

PRKN
E3 ubiquitin-protein ligase parkin

1

8

High-throughput

0.479

High

248152

NUPR1
Nuclear protein 1

1

2

High-throughput

0.479

High

325172

HEXI1
Protein HEXIM1

1

3

High-throughput

0.479

High

331433

KI20A
Kinesin-like protein KIF20A

1

8

High-throughput

0.479

High

930087

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

2

High-throughput

0.479

High

948965

CD81
CD81 antigen

1

1

High-throughput

0.479

High

955764

CDC42
Cell division control protein 42 homolog

1

1

High-throughput

0.479

High

1036004

KIF23
Kinesin-like protein KIF23

1

4

High-throughput

0.479

High

1040407

DYST
Dystonin

1

3

High-throughput

0.479

High

1115156

CUL4A
Cullin-4A

1

3

High-throughput

0.479

High

1116148

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

4

High-throughput

0.479

High

1141062

KIF14
Kinesin-like protein KIF14

1

3

High-throughput

0.479

High

1256149

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.479

High

1313546

SMC5
Structural maintenance of chromosomes protein 5

1

2

High-throughput

0.479

High

1364711

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

1366919

RND1
Rho-related GTP-binding protein Rho6

1

3

High-throughput

0.479

High

1380610

IGSF8
Immunoglobulin superfamily member 8

1

1

High-throughput

0.479

High

1407266

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

1

High-throughput

0.479

High

1433133

CHM4B
Charged multivesicular body protein 4b

1

3

High-throughput

0.479

High

1434264

PKHA4
Pleckstrin homology domain-containing family A member 4

1

14

High-throughput

0.479

High

1436568

ECT2
Protein ECT2

1

6

High-throughput

0.479

High

1438250

RHOF
Rho-related GTP-binding protein RhoF

1

2

High-throughput

0.479

High

1459355

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1490566

ARI1
E3 ubiquitin-protein ligase ARIH1

1

7

High-throughput

0.479

High

1270739

Q7KZS0
SUMO-conjugating enzyme UBC9

1

2

High-throughput

0.470

High

860410

RS9
Small ribosomal subunit protein uS4

1

0

High-throughput

0.458

High

1383284

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.458

High

1408161

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

1454117

LUZP4
Leucine zipper protein 4

1

0

Small-scale

0.458

High

988044

GRB2
Growth factor receptor-bound protein 2

1

6

High-throughput

0.445

High

1156719

NF2L2
Nuclear factor erythroid 2-related factor 2

1

3

High-throughput

0.445

High

1326157

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.445

High

1405543

ZBT18
Zinc finger and BTB domain-containing protein 18

1

3

High-throughput

0.445

High

158006

CTRO
Citron Rho-interacting kinase

1

6

High-throughput

0.437

High

599234

IL7RA
Interleukin-7 receptor subunit alpha

1

1

High-throughput

0.437

High

756091

MCM5
DNA replication licensing factor MCM5

1

3

High-throughput

0.437

High

786305

LONM
Lon protease homolog, mitochondrial

1

2

High-throughput

0.437

High

965343

WDR5
WD repeat-containing protein 5

1

3

High-throughput

0.437

High

1155920

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.437

High

1194465

LARP7
La-related protein 7

1

1

High-throughput

0.437

High

1197601

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

2

High-throughput

0.437

High

1229517

C19L1
CWF19-like protein 1

1

2

High-throughput

0.437

High

1271916

MEPCE
7SK snRNA methylphosphate capping enzyme

1

1

High-throughput

0.437

High

1418844

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

2

High-throughput

0.437

High

1419436

RHBT2
Rho-related BTB domain-containing protein 2

1

5

High-throughput

0.437

High

1437243

NANOG
Homeobox protein NANOG

1

1

High-throughput

0.437

High

839112

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

0

High-throughput

0.426

High

1402164

S22AC
Solute carrier family 22 member 12

1

0

High-throughput

0.426

High

766027

BMI1
Polycomb complex protein BMI-1

1

4

High-throughput

0.407

High

1257238

NEK10
Serine/threonine-protein kinase Nek10

1

5

High-throughput

0.407

High

822174

PSB10
Proteasome subunit beta type-10

1

0

High-throughput

0.279

Low

1415957

HIRP3
HIRA-interacting protein 3

1

0

High-throughput

0.279

Low

1458425

COMD3
COMM domain-containing protein 3

1

0

High-throughput

0.279

Low

1064047

ECHP
Peroxisomal bifunctional enzyme

1

0

High-throughput

0.268

Low

1398023

MF14A
Hippocampus abundant transcript 1 protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025