HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: RHBT2 (Q9BYZ6)
Rho-related BTB domain-containing protein 2 (Deleted in breast cancer 2 gene protein) (p83)
Gene: RHOBTB2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~fn3
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 727
+	Hs
		665192 EPHA2_HUMAN (1-976): 0: 1141: 100.00		CDC42_HUMAN (12-218): 7.09e-92: 286: 36.67
+	Hs
		872419 EPHA5_HUMAN (11-976): 0: 1127: 51.34		CDC42_HUMAN (12-218): 7.09e-92: 286: 36.67
+	Hs
		564420 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RHOQ_HUMAN (10-225): 1.24e-84: 267: 36.53
+	Hs
		564541 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RHOQ_HUMAN (10-225): 1.24e-84: 267: 36.53
+	Hs
		545218 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RAC2_HUMAN (12-219): 9.54e-73: 236: 36.97
+	Hs
		665191 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RAC3_HUMAN (12-208): 3.69e-72: 234: 39.50
+	Hs
		665201 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RAC1_HUMAN (12-220): 1.16e-71: 233: 35.38
+	Hs
		665208 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RHOG_HUMAN (12-218): 6.57e-71: 231: 36.19
+	Hs
		665194 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RHOA_HUMAN (16-216): 1.94e-70: 230: 35.29
+	Hs
		665197 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RB11A_HUMAN (5-252): 2.31e-70: 230: 16.34
+	Hs
		545394 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RAC2_HUMAN (12-219): 9.54e-73: 236: 36.97
+	Hs
		545285 EPHA5_HUMAN (11-976): 0: 1127: 51.34		RAC2_HUMAN (12-219): 9.54e-73: 236: 36.97
+	Hs
		892388 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RAC3_HUMAN (12-208): 3.69e-72: 234: 39.50
+	Hs
		872418 EPHA5_HUMAN (11-976): 0: 1127: 51.34		RAC3_HUMAN (12-208): 3.69e-72: 234: 39.50
+	Hs
		925297 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RAC1_HUMAN (12-220): 1.16e-71: 233: 35.38
+	Hs
		872423 EPHA5_HUMAN (11-976): 0: 1127: 51.34		RAC1_HUMAN (12-220): 1.16e-71: 233: 35.38
+	Hs
		951011 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RHOG_HUMAN (12-218): 6.57e-71: 231: 36.19
+	Hs
		872424 EPHA5_HUMAN (11-976): 0: 1127: 51.34		RHOG_HUMAN (12-218): 6.57e-71: 231: 36.19
+	Hs
		900497 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RHOA_HUMAN (16-216): 1.94e-70: 230: 35.29
+	Hs
		665387 EPHA3_HUMAN (24-976): 0: 1111: 51.19		RAC3_HUMAN (12-208): 3.69e-72: 234: 39.50