HitPredict

Interactor 1: EPHA3 (P29320)
Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1)
Gene: EPHA3

Interactor 2: EFNA3 (P52797)
Ephrin-A3 (EFL-2) (EHK1 ligand) (EHK1-L) (EPH-related receptor tyrosine kinase ligand 3) (LERK-3)
Gene: EFNA3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9195962
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ephrin~Ephrin_lbd
Common GO terms	GO:0005005 - transmembrane-ephrin receptor activity GO:0005886 - plasma membrane GO:0007411 - axon guidance GO:0048013 - ephrin receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 983 Hs			1 238
+	Hs
		856319 EPHA7_HUMAN (6-979): 0: 1198: 61.46		EFNA3_HUMAN (23-238): 6.17e-100: 292: 100.00
+	Hs
		595975 EPHA3_HUMAN (1-983): 0: 1248: 100.00		EFNA1_HUMAN (16-204): 3.98e-76: 230: 39.47
+	Hs
		665382 EPHA3_HUMAN (1-983): 0: 1248: 100.00		EFNA5_HUMAN (8-208): 1.93e-75: 229: 38.89
+	Mm
		139054 Q8BRB1_MOUSE (1-983): 0: 1240: 96.44		EFNA5_MOUSE (8-208): 3.05e-75: 229: 38.89
+	Hs
		665381 EPHA3_HUMAN (1-983): 0: 1248: 100.00		EFNB2_HUMAN (12-229): 4.24e-69: 216: 24.90
+	Hs
		665380 EPHA3_HUMAN (1-983): 0: 1248: 100.00		EFNA4_HUMAN (8-197): 2.58e-67: 208: 38.02
+	Dr
		47532 Q5ZEW1_DANRE (8-980): 0: 1205: 60.66		A0A8M1Q1X6_DANRE (1-222): 1.73e-82: 247: 59.91
+	Dr
		1140992 Q5ZEW1_DANRE (8-980): 0: 1205: 60.66		Q90YC5_DANRE (26-221): 3.6e-81: 243: 65.82
+	Hs
		665390 EPHA3_HUMAN (1-983): 0: 1248: 100.00		EFNB1_HUMAN (11-236): 1.95e-61: 197: 19.84
+	Dr
		945416 Q5ZEW1_DANRE (8-980): 0: 1205: 60.66		EFNA5_DANRE (8-214): 1.47e-75: 230: 38.39
+	Hs
		856595 EPHA5_HUMAN (7-983): 0: 1202: 65.97		EFNA5_HUMAN (8-208): 1.93e-75: 229: 38.89
+	Hs
		856606 EPHA7_HUMAN (6-979): 0: 1198: 61.46		EFNA5_HUMAN (8-208): 1.93e-75: 229: 38.89
+	Mm
		139053 EPHA7_MOUSE (6-979): 0: 1193: 61.77		EFNA5_MOUSE (8-208): 3.05e-75: 229: 38.89
+	Hs
		856508 EPHA5_HUMAN (7-983): 0: 1202: 65.97		EFNB2_HUMAN (12-229): 4.24e-69: 216: 24.90
+	Dr
		945415 Q5ZEW1_DANRE (8-980): 0: 1205: 60.66		EFNA2_DANRE (7-187): 4.47e-68: 209: 45.90
+	Dr
		1140993 Q5ZEW1_DANRE (8-980): 0: 1205: 60.66		Q90Z31_DANRE (16-229): 1.08e-63: 203: 23.89
+	Hs
		856385 EPHA7_HUMAN (6-979): 0: 1198: 61.46		EFNA4_HUMAN (8-197): 2.58e-67: 208: 38.02
+	Dr
		251124 Q5ZEW1_DANRE (8-980): 0: 1205: 60.66		EFNB2_DANRE (16-226): 6.29e-62: 198: 20.00
+	Hs
		957840 EPHA7_HUMAN (6-979): 0: 1198: 61.46		EFNB1_HUMAN (11-236): 1.95e-61: 197: 19.84
+	Hs
		217642 EPHA7_HUMAN (6-979): 0: 1198: 61.46		EFNA2_HUMAN (22-179): 6.16e-58: 184: 49.40