HitPredict

Interactor 1: EPHA3 (P29320)
Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1)
Gene: EPHA3

Interactor 2: EFNA4 (P52798)
Ephrin-A4 (EPH-related receptor tyrosine kinase ligand 4) (LERK-4)
Gene: EFNA4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9195962
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ephrin~Ephrin_lbd
Common GO terms	GO:0005005 - transmembrane-ephrin receptor activity GO:0005576 - extracellular region GO:0005886 - plasma membrane GO:0007411 - axon guidance GO:0048013 - ephrin receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 983 Hs			1 201
+	Hs
		665381 EPHA3_HUMAN (1-983): 0: 1248: 100.00		EFNB2_HUMAN (11-183): 1.14e-72: 224: 27.84
+	Hs
		665382 EPHA3_HUMAN (1-983): 0: 1248: 100.00		EFNA5_HUMAN (1-161): 6.37e-74: 224: 43.37
+	Mm
		139054 Q8BRB1_MOUSE (1-983): 0: 1240: 96.44		EFNA5_MOUSE (1-161): 1.96e-73: 223: 43.98
+	Hs
		595975 EPHA3_HUMAN (1-983): 0: 1248: 100.00		EFNA1_HUMAN (11-162): 3.84e-69: 211: 43.59
+	Hs
		856385 EPHA7_HUMAN (6-979): 0: 1198: 61.46		EFNA4_HUMAN (1-185): 1.68e-86: 255: 100.00
+	Hs
		665390 EPHA3_HUMAN (1-983): 0: 1248: 100.00		EFNB1_HUMAN (6-172): 1.5e-64: 204: 27.38
+	Hs
		665379 EPHA3_HUMAN (1-983): 0: 1248: 100.00		EFNA3_HUMAN (21-169): 8.45e-61: 191: 42.50
+	Hs
		856508 EPHA5_HUMAN (7-983): 0: 1202: 65.97		EFNB2_HUMAN (11-183): 1.14e-72: 224: 27.84
+	Hs
		856595 EPHA5_HUMAN (7-983): 0: 1202: 65.97		EFNA5_HUMAN (1-161): 6.37e-74: 224: 43.37
+	Hs
		856606 EPHA7_HUMAN (6-979): 0: 1198: 61.46		EFNA5_HUMAN (1-161): 6.37e-74: 224: 43.37
+	Mm
		139053 EPHA7_MOUSE (6-979): 0: 1193: 61.77		EFNA5_MOUSE (1-161): 1.96e-73: 223: 43.98
+	Dr
		945415 Q5ZEW1_DANRE (8-980): 0: 1205: 60.66		EFNA2_DANRE (1-169): 3.39e-68: 208: 43.68
+	Dr
		945416 Q5ZEW1_DANRE (8-980): 0: 1205: 60.66		EFNA5_DANRE (2-161): 9.32e-68: 208: 41.21
+	Hs
		957840 EPHA7_HUMAN (6-979): 0: 1198: 61.46		EFNB1_HUMAN (6-172): 1.5e-64: 204: 27.38
+	Dr
		251124 Q5ZEW1_DANRE (8-980): 0: 1205: 60.66		EFNB2_DANRE (29-183): 1.69e-60: 193: 32.05
+	Dr
		1140992 Q5ZEW1_DANRE (8-980): 0: 1205: 60.66		Q90YC5_DANRE (21-169): 4.71e-61: 191: 40.13
+	Dr
		1140993 Q5ZEW1_DANRE (8-980): 0: 1205: 60.66		Q90Z31_DANRE (14-168): 3.99e-59: 189: 26.42
+	Dr
		47532 Q5ZEW1_DANRE (8-980): 0: 1205: 60.66		A0A8M1Q1X6_DANRE (4-161): 2.54e-60: 189: 39.39
+	Hs
		856319 EPHA7_HUMAN (6-979): 0: 1198: 61.46		EFNA3_HUMAN (21-169): 8.45e-61: 191: 42.50
+	Hs
		217642 EPHA7_HUMAN (6-979): 0: 1198: 61.46		EFNA2_HUMAN (21-174): 3.64e-57: 181: 45.78