HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: RON (Q04912)
Macrophage-stimulating protein receptor (MSP receptor) (EC 2.7.10.1) (CDw136) (Protein-tyrosine kinase 8) (p185-Ron) (CD antigen CD136) [Cleaved into: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain]
Gene: MST1R

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	8918464
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0008284 - positive regulation of cell population proliferation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 1400
+	Hs
		441442 SHC1_HUMAN (1-583): 0: 531: 100.00		MET_HUMAN (1-1391): 0: 1065: 32.44
+	Hs
		441524 SHC4_HUMAN (7-581): 1.07e-136: 413: 45.53		MET_HUMAN (1-1391): 0: 1065: 32.44
+	Hs
		441545 SHC3_HUMAN (6-582): 3.32e-127: 387: 45.47		MET_HUMAN (1-1391): 0: 1065: 32.44
+	Hs
		441481 SHC2_HUMAN (56-582): 4.56e-116: 358: 44.88		MET_HUMAN (1-1391): 0: 1065: 32.44
+	Hs
		441502 GRB14_HUMAN (66-579): 1.66e-73: 246: 14.41		MET_HUMAN (1-1391): 0: 1065: 32.44
+	Hs
		666049 SHC1_HUMAN (1-583): 0: 531: 100.00		EPHA4_HUMAN (557-1381): 4.36e-174: 547: 17.21
+	Hs
		666048 SHC1_HUMAN (1-583): 0: 531: 100.00		EPHA5_HUMAN (557-1362): 5.19e-165: 524: 16.53
+	Hs
		665145 SHC1_HUMAN (1-583): 0: 531: 100.00		EPHA2_HUMAN (557-1377): 5.9e-160: 509: 16.75
+	Hs
		507872 SHC1_HUMAN (1-583): 0: 531: 100.00		FGFR1_HUMAN (767-1397): 8.56e-114: 379: 22.74
+	Hs
		601467 SHC1_HUMAN (1-583): 0: 531: 100.00		FGFR2_HUMAN (784-1397): 2.76e-113: 378: 23.33
+	Hs
		666080 SHC1_HUMAN (1-583): 0: 531: 100.00		FAK1_HUMAN (1022-1395): 3.19e-104: 359: 30.73
+	Mm
		957226 SHC1_MOUSE (1-583): 0: 527: 94.51		UFO_MOUSE (1062-1348): 4.1e-57: 216: 41.14
+	Hs
		435550 SHC1_HUMAN (1-583): 0: 531: 100.00		IGF1R_HUMAN (1072-1343): 3.56e-52: 204: 37.93
+	Hs
		411312 SHC1_HUMAN (1-583): 0: 531: 100.00		INSR_HUMAN (1073-1338): 8.47e-51: 199: 38.73
+	Hs
		666110 SHC1_HUMAN (1-583): 0: 531: 100.00		FAK2_HUMAN (1075-1384): 4.28e-51: 199: 35.65
+	Hs
		433604 SHC1_HUMAN (1-583): 0: 531: 100.00		LYN_HUMAN (1088-1357): 6.87e-51: 190: 39.11
+	Hs
		666029 SHC1_HUMAN (1-583): 0: 531: 100.00		CSK_HUMAN (1086-1344): 9.72e-51: 188: 40.00
+	Mm
		963046 SHC2_MOUSE (43-582): 6.38e-127: 386: 45.91		UFO_MOUSE (1062-1348): 4.1e-57: 216: 41.14
+	Hs
		435642 GRB14_HUMAN (66-579): 1.66e-73: 246: 14.41		IGF1R_HUMAN (1072-1343): 3.56e-52: 204: 37.93
+	Hs
		411383 GRB14_HUMAN (66-579): 1.66e-73: 246: 14.41		INSR_HUMAN (1073-1338): 8.47e-51: 199: 38.73