Protein: ZAP70
Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase)

Gene: ZAP70
Organism: Mus musculus
Interactions: 51
UniProt ID: P43404

Gene Ontology (top 5):
GO:0001772 - immunological synapse
GO:0001784 - phosphotyrosine residue binding
GO:0002250 - adaptive immune response
GO:0004672 - protein kinase activity
GO:0004713 - protein tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

440274

LCK
Proto-oncogene tyrosine-protein kinase LCK

2

19

Small-scale

0.776

High

849105

CRK
Adapter molecule crk

1

20

Small-scale

0.665

High

849098

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

1

17

High-throughput

0.646

High

664095

CD3Z
T-cell surface glycoprotein CD3 zeta chain

3

7

Small-scale

0.633

High

699347

VAV
Proto-oncogene vav

1

20

Small-scale

0.618

High

849090

CRKL
Crk-like protein

1

20

Small-scale

0.618

High

849106

DLG1
Disks large homolog 1

1

20

Small-scale

0.618

High

849111

IRAK4
Interleukin-1 receptor-associated kinase 4

1

1

Small-scale

0.618

High

849112

SLAP2
Src-like-adapter 2

1

20

Small-scale

0.618

High

849119

PK3CG
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

1

18

Small-scale

0.618

High

419942

B3AT
Band 3 anion transport protein

2

10

Small-scale

0.602

High

838210

STAT1
Signal transducer and activator of transcription 1

1

20

High-throughput

0.575

High

849094

1433T
14-3-3 protein theta

1

20

High-throughput

0.575

High

849099

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

1

20

High-throughput

0.575

High

849100

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.575

High

849103

CDC37
Hsp90 co-chaperone Cdc37

1

20

High-throughput

0.575

High

849108

DOCK2
Dedicator of cytokinesis protein 2

1

9

High-throughput

0.575

High

849117

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.575

High

651491

CBL
E3 ubiquitin-protein ligase CBL

2

20

Small-scale

0.563

High

849101

SLAP1
Src-like-adapter

1

20

Small-scale

0.553

High

849113

NFAM1
NFAT activation molecule 1

1

1

Small-scale

0.536

High

378890

CD8A
T-cell surface glycoprotein CD8 alpha chain

1

1

Small-scale

0.479

High

849095

WASP
Actin nucleation-promoting factor WAS

1

20

Small-scale

0.479

High

378910

TVB1
T-cell receptor beta chain V region 3H.25

1

6

High-throughput

0.445

High

378911

TVB86
T-cell receptor beta chain V region 86T1

1

6

High-throughput

0.445

High

406945

TVB4
T-cell receptor beta chain V region LB2

1

5

High-throughput

0.445

High

406946

TVB5
T-cell receptor beta chain V region C5

1

7

High-throughput

0.445

High

406947

TVB6
T-cell receptor beta chain V region E1

1

6

High-throughput

0.445

High

407226

CD3D
T-cell surface glycoprotein CD3 delta chain

1

6

High-throughput

0.445

High

441578

TVB7
T-cell receptor beta chain V region CTL-F3

1

7

High-throughput

0.445

High

550548

CD3G
T-cell surface glycoprotein CD3 gamma chain

1

6

High-throughput

0.445

High

651057

CD3E
T-cell surface glycoprotein CD3 epsilon chain

1

4

High-throughput

0.445

High

663840

ITAL
Integrin alpha-L

1

15

High-throughput

0.445

High

670047

MCM3
DNA replication licensing factor MCM3

1

7

High-throughput

0.445

High

849091

MCM5
DNA replication licensing factor MCM5

1

5

High-throughput

0.445

High

849092

PRS6B
26S proteasome regulatory subunit 6B

1

1

High-throughput

0.445

High

849093

PSME3
Proteasome activator complex subunit 3

1

1

High-throughput

0.445

High

849096

LY9
T-lymphocyte surface antigen Ly-9

1

20

High-throughput

0.445

High

849097

CBLB
E3 ubiquitin-protein ligase CBL-B

1

20

High-throughput

0.445

High

849102

CD6
T-cell differentiation antigen CD6

1

6

High-throughput

0.445

High

849104

TFR1
Transferrin receptor protein 1

1

1

High-throughput

0.445

High

849107

RCC2
Protein RCC2

1

5

High-throughput

0.445

High

849109

SIT1
Signaling threshold-regulating transmembrane adapter 1

1

4

High-throughput

0.445

High

849110

VWA8
von Willebrand factor A domain-containing protein 8

1

3

High-throughput

0.445

High

849116

PPAC
Low molecular weight phosphotyrosine protein phosphatase

1

5

High-throughput

0.445

High

849118

XPO2
Exportin-2

1

1

High-throughput

0.445

High

379169

TRAC
T-cell receptor alpha chain constant

1

0

High-throughput

0.426

High

625160

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.426

High

379170

TCB2
T-cell receptor beta-2 chain C region

1

8

High-throughput

0.407

High

849114

TADBP
TAR DNA-binding protein 43

1

14

High-throughput

0.407

High

849115

SFXN1
Sideroflexin-1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025