HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: GAB2 (Q9UQC2)
GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100)
Gene: GAB2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.692

Property	Details
Experiments	12135708, 11782427, 14982882, 10704825
Identification Methods	affinity chromatography technology, coimmunoprecipitation, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0008284 - positive regulation of cell population proliferation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 676
+	Mm
		957233 SHC1_MOUSE (1-583): 0: 527: 94.51		Q3ZB59_MOUSE (1-676): 0: 714: 91.31
+	Mm
		957250 SHC1_MOUSE (1-583): 0: 527: 94.51		GAB2_MOUSE (1-676): 0: 714: 91.16
+	Hs
		666100 SHC1_HUMAN (1-583): 0: 531: 100.00		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Mm
		957247 SHC1_MOUSE (1-583): 0: 527: 94.51		GAB1_MOUSE (3-675): 0: 643: 37.45
+	Hs
		1035394 SHC3_HUMAN (6-582): 3.32e-127: 387: 45.47		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		557834 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		GAB2_HUMAN (1-676): 0: 763: 100.00
+	Hs
		655510 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		GAB2_HUMAN (1-676): 0: 763: 100.00
+	Mm
		643089 P85A_MOUSE (300-581): 6.66e-38: 151: 15.99		Q3ZB59_MOUSE (1-676): 0: 714: 91.31
+	Hs
		548703 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		1035413 VAV3_HUMAN (190-579): 2.86e-47: 179: 14.52		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		209049 NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		855792 VAV2_HUMAN (189-579): 1.9e-42: 165: 12.97		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		442825 HCK_HUMAN (348-575): 2.72e-43: 164: 17.16		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		557681 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		275569 BCAR3_HUMAN (379-583): 3.82e-38: 152: 23.83		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		655356 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Mm
		643113 P85A_MOUSE (300-581): 6.66e-38: 151: 15.99		GAB1_MOUSE (3-675): 0: 643: 37.45
+	Hs
		1153427 GULP1_HUMAN (137-418): 7.16e-48: 171: 19.79		PKHA7_HUMAN (6-456): 1.7e-80: 278: 14.62
+	Dm
		1358412 Q9V3C8_DROME (128-581): 3.26e-84: 270: 36.56		DOS_DROME (8-218): 1.26e-36: 149: 30.22
+	Hs
		209111 NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83		SESQ1_HUMAN (2-132): 1.35e-28: 116: 22.63