HitPredict

Interactor 1: CCNC (P24863)
Cyclin-C (SRB11 homolog) (hSRB11)
Gene: CCNC

Interactor 2: MED13 (Q9UHV7)
Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250)
Gene: MED13

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.727

Property	Details
Experiments	29568061, 24981860, 26186194, 28514442, 33961781, unassigned3799
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016592 - mediator complex GO:0045944 - positive regulation of transcription by RNA polymerase II GO:1990508 - CKM complex
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 283 Hs			1 2174
+	Hs
		95764 E5RFK5_HUMAN (1-257): 8.37e-74: 229: 100.00		MED13_HUMAN (1-2174): 0: 3460: 100.00
+	Hs
		666857 CCNC_HUMAN (1-283): 1.06e-79: 244: 100.00		MD13L_HUMAN (2-2174): 0: 3190: 51.68
+	Hs
		95748 E5RFK5_HUMAN (1-257): 8.37e-74: 229: 100.00		MD13L_HUMAN (2-2174): 0: 3190: 51.68
+	Dm
		668159 CCNC_DROME (1-256): 2.01e-75: 232: 71.60		MED13_DROME (776-947): 6.04e-50: 198: 25.11
+	At
		99937 CCC12_ARATH (1-257): 6.91e-70: 218: 39.00		MED13_ARATH (1331-1392): 8.09e-21: 103: 40.32