Protein: MED13
Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250)

Gene: MED13
Organism: Homo sapiens
Interactions: 85
UniProt ID: Q9UHV7

Gene Ontology (top 5):
GO:0003712 - transcription coregulator activity
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

881620

CDK8
Cyclin-dependent kinase 8

17

7

Small-scale

0.985

High

1416409

CDK19
Cyclin-dependent kinase 19

7

7

Small-scale

0.962

High

1372211

MED12
Mediator of RNA polymerase II transcription subunit 12

6

4

High-throughput

0.945

High

1259078

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

2

1

High-throughput

0.776

High

1295682

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

2

5

High-throughput

0.776

High

49032

MED19
Mediator of RNA polymerase II transcription subunit 19

10

2

Small-scale

0.756

High

1151307

MED1
Mediator of RNA polymerase II transcription subunit 1

9

4

Small-scale

0.752

High

1413642

MED10
Mediator of RNA polymerase II transcription subunit 10

8

2

Small-scale

0.749

High

1446542

MED4
Mediator of RNA polymerase II transcription subunit 4

7

2

Small-scale

0.748

High

1431403

MED28
Mediator of RNA polymerase II transcription subunit 28

7

1

Small-scale

0.746

High

1108414

MED21
Mediator of RNA polymerase II transcription subunit 21

6

1

High-throughput

0.736

High

1414151

MED18
Mediator of RNA polymerase II transcription subunit 18

6

2

Small-scale

0.736

High

1451891

MED29
Mediator of RNA polymerase II transcription subunit 29

6

2

Small-scale

0.736

High

219525

MED7
Mediator of RNA polymerase II transcription subunit 7

6

2

Small-scale

0.735

High

1451137

MED9
Mediator of RNA polymerase II transcription subunit 9

6

1

Small-scale

0.730

High

666925

CCNC
Cyclin-C

6

5

High-throughput

0.727

High

1460085

MED23
Mediator of RNA polymerase II transcription subunit 23

5

3

Small-scale

0.711

High

1380233

FBXW7
F-box/WD repeat-containing protein 7

5

1

Small-scale

0.711

High

336039

MED26
Mediator of RNA polymerase II transcription subunit 26

4

1

Small-scale

0.694

High

1450388

MED17
Mediator of RNA polymerase II transcription subunit 17

4

2

High-throughput

0.687

High

1460087

MED31
Mediator of RNA polymerase II transcription subunit 31

3

2

High-throughput

0.671

High

1134815

NR1I3
Nuclear receptor subfamily 1 group I member 3

3

8

High-throughput

0.667

High

1460084

MED13
Mediator of RNA polymerase II transcription subunit 13

1

1

High-throughput

0.665

High

239631

MED14
Mediator of RNA polymerase II transcription subunit 14

3

4

High-throughput

0.662

High

282429

MED24
Mediator of RNA polymerase II transcription subunit 24

3

2

High-throughput

0.662

High

1149719

MED22
Mediator of RNA polymerase II transcription subunit 22

3

1

High-throughput

0.662

High

1241422

MED27
Mediator of RNA polymerase II transcription subunit 27

3

2

High-throughput

0.662

High

1393386

MED30
Mediator of RNA polymerase II transcription subunit 30

3

2

Small-scale

0.662

High

1436787

MED20
Mediator of RNA polymerase II transcription subunit 20

3

2

High-throughput

0.662

High

1453731

MED11
Mediator of RNA polymerase II transcription subunit 11

3

2

High-throughput

0.662

High

1401575

MED15
Mediator of RNA polymerase II transcription subunit 15

3

2

Small-scale

0.650

High

397162

ESR1
Estrogen receptor

3

7

Small-scale

0.641

High

787901

SRBP1
Sterol regulatory element-binding protein 1

3

0

Small-scale

0.613

High

287827

MED6
Mediator of RNA polymerase II transcription subunit 6

2

3

High-throughput

0.601

High

1259293

MED25
Mediator of RNA polymerase II transcription subunit 25

2

1

Small-scale

0.601

High

1391344

MED8
Mediator of RNA polymerase II transcription subunit 8

2

2

High-throughput

0.601

High

1460086

MED16
Mediator of RNA polymerase II transcription subunit 16

2

2

High-throughput

0.601

High

920338

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.586

High

543548

VDR
Vitamin D3 receptor

2

3

Small-scale

0.584

High

1367524

ESR2
Estrogen receptor beta

2

7

High-throughput

0.571

High

1161428

HIF1A
Hypoxia-inducible factor 1-alpha

1

2

Small-scale

0.536

High

1243786

FXL19
F-box/LRR-repeat protein 19

1

1

High-throughput

0.536

High

446080

ENOA
Alpha-enolase

1

0

High-throughput

0.518

High

1395312

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.518

High

76444

B4DUB1
cyclin-dependent kinase

1

7

High-throughput

0.514

High

143311

NFIB
Nuclear factor 1 B-type

1

6

High-throughput

0.479

High

260582

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

283563

TAD2A
Transcriptional adapter 2-alpha

1

2

High-throughput

0.479

High

474354

NFIC
Nuclear factor 1 C-type

1

9

High-throughput

0.479

High

520432

ANDR
Androgen receptor

1

7

High-throughput

0.479

High

621786

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.479

High

622004

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

1

High-throughput

0.479

High

667499

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

1

High-throughput

0.479

High

723134

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

1

High-throughput

0.479

High

787811

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

1

High-throughput

0.479

High

912151

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

1

High-throughput

0.479

High

976173

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

1

High-throughput

0.479

High

1008393

PRKDC
DNA-dependent protein kinase catalytic subunit

1

1

Small-scale

0.479

High

1088082

NFIA
Nuclear factor 1 A-type

1

6

High-throughput

0.479

High

1089051

TP53B
TP53-binding protein 1

1

2

High-throughput

0.479

High

1133720

NFIX
Nuclear factor 1 X-type

1

6

High-throughput

0.479

High

1212054

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

2

High-throughput

0.479

High

1235689

NIPBL
Nipped-B-like protein

1

2

High-throughput

0.479

High

1257836

ACD11
Acyl-CoA dehydrogenase family member 11

1

1

High-throughput

0.479

High

1313074

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

1

High-throughput

0.479

High

1460089

SCC4
MAU2 chromatid cohesion factor homolog

1

1

High-throughput

0.479

High

283630

SUPT3
Transcription initiation protein SPT3 homolog

1

0

Small-scale

0.458

High

390803

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.458

High

1151397

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.458

High

1336873

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

0

Small-scale

0.458

High

1400095

QKI
KH domain-containing RNA-binding protein QKI

1

0

High-throughput

0.458

High

1434842

STN1
CST complex subunit STN1

1

0

High-throughput

0.458

High

1369174

KAT2A
Histone acetyltransferase KAT2A

1

3

Small-scale

0.445

High

1401902

NUDC1
NudC domain-containing protein 1

1

1

High-throughput

0.445

High

1460088

TRRAP
Transformation/transcription domain-associated protein

1

1

Small-scale

0.445

High

273291

T22D2
TSC22 domain family protein 2

1

1

Small-scale

0.439

High

253995

LPXN
Leupaxin

1

0

High-throughput

0.426

High

95764

E5RFK5
Cyclin-C

1

5

High-throughput

0.407

High

352650

TCL1B
T-cell leukemia/lymphoma protein 1B

3

0

High-throughput

0.347

High

1294779

PTH
Peptidyl-tRNA hydrolase

1

0

High-throughput

0.279

Low

1005563

GBRE
Gamma-aminobutyric acid receptor subunit epsilon

1

0

High-throughput

0.249

Low

1007331

TCPB
T-complex protein 1 subunit beta

1

0

Small-scale

0.249

Low

1448538

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.238

Low

516884

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025