Protein: MD13L
Mediator of RNA polymerase II transcription subunit 13-like (Mediator complex subunit 13-like) (Thyroid hormone receptor-associated protein 2) (Thyroid hormone receptor-associated protein complex 240 kDa component-like)

Gene: MD13L, MED13L
Organism: Homo sapiens
Interactions: 102
UniProt ID: Q71F56

Gene Ontology (top 5):
GO:0003713 - transcription coactivator activity
GO:0005654 - nucleoplasm
GO:0016592 - mediator complex
GO:0045944 - positive regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

881552

CDK8
Cyclin-dependent kinase 8

9

7

High-throughput

0.974

High

1259068

CDK19
Cyclin-dependent kinase 19

6

7

High-throughput

0.947

High

1259054

MED12
Mediator of RNA polymerase II transcription subunit 12

4

4

High-throughput

0.895

High

1259078

MED13
Mediator of RNA polymerase II transcription subunit 13

2

1

High-throughput

0.776

High

48979

MED19
Mediator of RNA polymerase II transcription subunit 19

7

2

High-throughput

0.750

High

1259071

MED4
Mediator of RNA polymerase II transcription subunit 4

6

2

High-throughput

0.732

High

666857

CCNC
Cyclin-C

6

4

High-throughput

0.729

High

1108360

MED21
Mediator of RNA polymerase II transcription subunit 21

5

1

High-throughput

0.720

High

1151264

MED1
Mediator of RNA polymerase II transcription subunit 1

5

4

Small-scale

0.718

High

1259069

MED28
Mediator of RNA polymerase II transcription subunit 28

5

1

High-throughput

0.718

High

1259066

MED10
Mediator of RNA polymerase II transcription subunit 10

5

2

Small-scale

0.716

High

1259073

MED9
Mediator of RNA polymerase II transcription subunit 9

5

1

Small-scale

0.712

High

219495

MED7
Mediator of RNA polymerase II transcription subunit 7

4

2

High-throughput

0.699

High

1259074

MED29
Mediator of RNA polymerase II transcription subunit 29

4

2

High-throughput

0.699

High

1259055

FBXW7
F-box/WD repeat-containing protein 7

4

1

Small-scale

0.692

High

1259072

MED17
Mediator of RNA polymerase II transcription subunit 17

4

2

High-throughput

0.691

High

1259067

MED18
Mediator of RNA polymerase II transcription subunit 18

3

2

High-throughput

0.675

High

1259083

MED31
Mediator of RNA polymerase II transcription subunit 31

3

2

High-throughput

0.675

High

239591

MED14
Mediator of RNA polymerase II transcription subunit 14

3

4

High-throughput

0.667

High

336006

MED26
Mediator of RNA polymerase II transcription subunit 26

3

1

High-throughput

0.667

High

1149692

MED22
Mediator of RNA polymerase II transcription subunit 22

3

1

High-throughput

0.667

High

1241387

MED27
Mediator of RNA polymerase II transcription subunit 27

3

2

High-throughput

0.667

High

1259070

MED20
Mediator of RNA polymerase II transcription subunit 20

3

2

High-throughput

0.667

High

1259079

MED23
Mediator of RNA polymerase II transcription subunit 23

3

3

High-throughput

0.656

High

1259048

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

1

5

High-throughput

0.618

High

282395

MED24
Mediator of RNA polymerase II transcription subunit 24

2

2

High-throughput

0.611

High

1088885

TP53B
TP53-binding protein 1

2

2

High-throughput

0.611

High

1259057

MED8
Mediator of RNA polymerase II transcription subunit 8

2

2

High-throughput

0.611

High

1259075

MED11
Mediator of RNA polymerase II transcription subunit 11

2

2

High-throughput

0.611

High

1217531

MRCKA
Serine/threonine-protein kinase MRCK alpha

1

0

High-throughput

0.578

High

132859

ODPX
Pyruvate dehydrogenase protein X component, mitochondrial

1

3

High-throughput

0.536

High

246707

KDM1A
Lysine-specific histone demethylase 1A

1

1

High-throughput

0.536

High

774079

ADDA
Alpha-adducin

1

4

High-throughput

0.536

High

788075

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

3

High-throughput

0.536

High

1161311

HIF1A
Hypoxia-inducible factor 1-alpha

1

2

Small-scale

0.536

High

1259058

MED30
Mediator of RNA polymerase II transcription subunit 30

1

2

High-throughput

0.536

High

943261

RBM11
Splicing regulator RBM11

1

0

High-throughput

0.518

High

76427

B4DUB1
cyclin-dependent kinase

1

7

High-throughput

0.514

High

250673

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

0

High-throughput

0.513

High

539200

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

0

High-throughput

0.513

High

1097378

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.513

High

1123574

ZMYM3
Zinc finger MYM-type protein 3

1

0

High-throughput

0.513

High

1259052

HDAC2
Histone deacetylase 2

1

0

High-throughput

0.513

High

1259053

ARHG2
Rho guanine nucleotide exchange factor 2

1

0

High-throughput

0.513

High

276374

LIPA2
Liprin-alpha-2

1

1

High-throughput

0.489

High

471102

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.489

High

522449

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

3

High-throughput

0.489

High

539353

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

3

High-throughput

0.489

High

721022

CLIP1
CAP-Gly domain-containing linker protein 1

1

1

High-throughput

0.489

High

1035407

ODO1
2-oxoglutarate dehydrogenase complex component E1

1

1

High-throughput

0.489

High

1210886

CE170
Centrosomal protein of 170 kDa

1

2

High-throughput

0.489

High

1243752

FXL19
F-box/LRR-repeat protein 19

1

1

High-throughput

0.489

High

1259060

AGAP3
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3

1

1

High-throughput

0.489

High

1259065

NPAS1
Neuronal PAS domain-containing protein 1

1

2

High-throughput

0.489

High

1259076

CLIP2
CAP-Gly domain-containing linker protein 2

1

1

High-throughput

0.489

High

1259077

ADDG
Gamma-adducin

1

1

High-throughput

0.489

High

1259080

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

1

High-throughput

0.489

High

1259081

WDR37
WD repeat-containing protein 37

1

3

High-throughput

0.489

High

143073

NFIB
Nuclear factor 1 B-type

1

6

High-throughput

0.479

High

260107

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

287800

MED6
Mediator of RNA polymerase II transcription subunit 6

1

3

High-throughput

0.479

High

474085

NFIC
Nuclear factor 1 C-type

1

9

High-throughput

0.479

High

520156

ANDR
Androgen receptor

1

7

High-throughput

0.479

High

621674

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.479

High

621903

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

1

High-throughput

0.479

High

667351

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

1

High-throughput

0.479

High

723004

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

1

High-throughput

0.479

High

787756

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

1

High-throughput

0.479

High

912077

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

1

High-throughput

0.479

High

976107

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

1

High-throughput

0.479

High

1087824

NFIA
Nuclear factor 1 A-type

1

6

High-throughput

0.479

High

1132777

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

1

High-throughput

0.479

High

1235640

NIPBL
Nipped-B-like protein

1

2

High-throughput

0.479

High

1259049

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

1

High-throughput

0.479

High

1259051

ESR2
Estrogen receptor beta

1

7

High-throughput

0.479

High

1259062

MED15
Mediator of RNA polymerase II transcription subunit 15

1

2

High-throughput

0.479

High

1259082

MED16
Mediator of RNA polymerase II transcription subunit 16

1

2

High-throughput

0.479

High

1259084

SCC4
MAU2 chromatid cohesion factor homolog

1

1

High-throughput

0.479

High

872462

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

886981

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.458

High

1259063

NUDC1
NudC domain-containing protein 1

1

1

High-throughput

0.445

High

1257778

ACD11
Acyl-CoA dehydrogenase family member 11

1

1

High-throughput

0.437

High

95748

E5RFK5
Cyclin-C

1

4

High-throughput

0.407

High

391629

FRIH
Ferritin heavy chain

1

0

High-throughput

0.279

Low

484576

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

833301

PERI
Peripherin

1

0

High-throughput

0.279

Low

1048568

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.279

Low

1191587

RABL6
Rab-like protein 6

1

0

High-throughput

0.279

Low

1250560

PACS1
Phosphofurin acidic cluster sorting protein 1

1

0

High-throughput

0.279

Low

1259047

RUFY3
Protein RUFY3

1

0

High-throughput

0.279

Low

1259050

IRGQ
Immunity-related GTPase family Q protein

1

0

High-throughput

0.279

Low

1259056

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

0

High-throughput

0.279

Low

1259061

ALS2
Alsin

1

0

High-throughput

0.279

Low

1259064

SORT
Sortilin

1

0

High-throughput

0.279

Low

1013411

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.269

Low

1164436

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.269

Low

532701

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.249

Low

970690

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

1214713

ATD3B
ATPase family AAA domain-containing protein 3B

1

0

High-throughput

0.249

Low

1259059

ZDH15
Palmitoyltransferase ZDHHC15

1

0

Small-scale

0.249

Low

2942

KV108
Immunoglobulin kappa variable 1-8

1

0

High-throughput

0.232

Low

379263

IGHG1
Immunoglobulin heavy constant gamma 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025