HitPredict

Interactor 1: GNA11 (P29992)
Guanine nucleotide-binding protein subunit alpha-11 (G alpha-11) (G-protein subunit alpha-11) (Guanine nucleotide-binding protein G(y) subunit alpha)
Gene: GNA11

Interactor 2: GBG3 (P63215)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
Gene: GNG3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003924 - GTPase activity GO:0005834 - heterotrimeric G-protein complex GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 359 Hs			1 75
+	Hs
		837602 GNAQ_HUMAN (1-359): 1.3e-168: 475: 90.25		GBG3_HUMAN (1-75): 2.04e-30: 103: 100.00
+	Hs
		837590 GNAQ_HUMAN (1-359): 1.3e-168: 475: 90.25		GBG4_HUMAN (1-75): 4.61e-29: 100: 69.33
+	Hs
		837595 GNAQ_HUMAN (1-359): 1.3e-168: 475: 90.25		GBG2_HUMAN (5-75): 2.64e-28: 98.2: 76.06
+	Hs
		670436 GNA11_HUMAN (1-359): 1.18e-165: 468: 100.00		GBG4_HUMAN (1-75): 4.61e-29: 100: 69.33
+	Hs
		670442 GNA11_HUMAN (1-359): 1.18e-165: 468: 100.00		GBG2_HUMAN (5-75): 2.64e-28: 98.2: 76.06
+	Hs
		926667 GNAI1_HUMAN (7-358): 3.66e-163: 462: 51.70		GBG3_HUMAN (1-75): 2.04e-30: 103: 100.00
+	Hs
		837664 GNAQ_HUMAN (1-359): 1.3e-168: 475: 90.25		GBG8_HUMAN (7-75): 6.35e-25: 89.3: 56.52
+	Hs
		837675 GNAI1_HUMAN (7-358): 3.66e-163: 462: 51.70		GBG4_HUMAN (1-75): 4.61e-29: 100: 69.33
+	Hs
		837659 GNAQ_HUMAN (1-359): 1.3e-168: 475: 90.25		GBG12_HUMAN (8-75): 1.12e-23: 86.3: 60.29
+	Hs
		887099 GNAI1_HUMAN (7-358): 3.66e-163: 462: 51.70		GBG2_HUMAN (5-75): 2.64e-28: 98.2: 76.06
+	Hs
		837591 GNAQ_HUMAN (1-359): 1.3e-168: 475: 90.25		GBG10_HUMAN (7-75): 2.48e-22: 82.8: 50.73
+	Hs
		670493 GNA11_HUMAN (1-359): 1.18e-165: 468: 100.00		GBG8_HUMAN (7-75): 6.35e-25: 89.3: 56.52
+	Hs
		837603 GNAQ_HUMAN (1-359): 1.3e-168: 475: 90.25		GBG5_HUMAN (7-75): 1.42e-21: 80.9: 46.38
+	Hs
		837601 GNAQ_HUMAN (1-359): 1.3e-168: 475: 90.25		GBG1_HUMAN (5-74): 5.36e-20: 77: 32.88
+	Hs
		229239 GNAI1_HUMAN (7-358): 3.66e-163: 462: 51.70		GBG7_HUMAN (7-75): 5.89e-25: 89.3: 60.87
+	Hs
		670437 GNA11_HUMAN (1-359): 1.18e-165: 468: 100.00		GBG10_HUMAN (7-75): 2.48e-22: 82.8: 50.73
+	Hs
		670456 GNA11_HUMAN (1-359): 1.18e-165: 468: 100.00		GBG5_HUMAN (7-75): 1.42e-21: 80.9: 46.38
+	Hs
		670454 GNA11_HUMAN (1-359): 1.18e-165: 468: 100.00		GBG1_HUMAN (5-74): 5.36e-20: 77: 32.88
+	Hs
		837689 GNAI1_HUMAN (7-358): 3.66e-163: 462: 51.70		GBG10_HUMAN (7-75): 2.48e-22: 82.8: 50.73
+	Hs
		926668 GNAI1_HUMAN (7-358): 3.66e-163: 462: 51.70		GBG5_HUMAN (7-75): 1.42e-21: 80.9: 46.38