HitPredict - High confidence protein-protein interactions

Interactor 1: PRDX5 (P30044)
Peroxiredoxin-5, mitochondrial (EC 1.11.1.24) (Alu corepressor 1) (Antioxidant enzyme B166) (AOEB166) (Liver tissue 2D-page spot 71B) (PLP) (Peroxiredoxin V) (Prx-V) (Peroxisomal antioxidant enzyme) (TPx type VI) (Thioredoxin peroxidase PMP20) (Thioredoxin-dependent peroxiredoxin 5)
Gene: PRDX5

Interactor 2: PRDX5 (P30044)
Peroxiredoxin-5, mitochondrial (EC 1.11.1.24) (Alu corepressor 1) (Antioxidant enzyme B166) (AOEB166) (Liver tissue 2D-page spot 71B) (PLP) (Peroxiredoxin V) (Prx-V) (Peroxisomal antioxidant enzyme) (TPx type VI) (Thioredoxin peroxidase PMP20) (Thioredoxin-dependent peroxiredoxin 5)
Gene: PRDX5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.757

Property	Details
Experiments	15046979
Identification Methods	molecular sieving, x-ray crystallography, comigration in sds page
Interaction Type	direct interaction, covalent binding

Property	Details
Interacting Pfam domains	Redoxin~Redoxin
Common GO terms	GO:0001016 - RNA polymerase III transcription regulatory region sequence-specific DNA binding GO:0004601 - peroxidase activity GO:0005102 - signaling receptor binding GO:0005615 - extracellular space GO:0005634 - nucleus and 27 others more... GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005759 - mitochondrial matrix GO:0005777 - peroxisome GO:0005782 - peroxisomal matrix GO:0005829 - cytosol GO:0006954 - inflammatory response GO:0006979 - response to oxidative stress GO:0008379 - thioredoxin peroxidase activity GO:0016209 - antioxidant activity GO:0016480 - negative regulation of transcription by RNA polymerase III GO:0031410 - cytoplasmic vesicle GO:0032967 - positive regulation of collagen biosynthetic process GO:0034599 - cellular response to oxidative stress GO:0034614 - cellular response to reactive oxygen species GO:0042744 - hydrogen peroxide catabolic process GO:0043027 - cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043066 - negative regulation of apoptotic process GO:0043231 - intracellular membrane-bounded organelle GO:0045454 - cell redox homeostasis GO:0048471 - perinuclear region of cytoplasm GO:0051354 - negative regulation of oxidoreductase activity GO:0060785 - regulation of apoptosis involved in tissue homeostasis GO:0070062 - extracellular exosome GO:0070995 - NADPH oxidation GO:0072541 - peroxynitrite reductase activity GO:2001057 - reactive nitrogen species metabolic process
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	214
Hs

1	214

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024