Interactor 1: CCND1 (P25322)
G1/S-specific cyclin-D1
Gene: CCND1
Interactor 2: CDK4 (P30285)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (CRK3) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4
Species: Mus musculus
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.97 | 1.00 | 0.987 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 16331266, 21306487, 17699765, 20516642, 12970760, 23707388, 16627785, 17081987, 16102793, 12588994, 1423597, 10348346, 17940036, 16864783, 16413468, 16413469, 19409388, 17948060, 20951943, 21242975 and 1 others
more... |
| Identification Methods | two hybrid, affinity chromatography technology, pull down, biochemical, coimmunoprecipitation, molecular sieving, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation |
| Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Cyclin_C~Pkinase, Cyclin_N~Pkinase |
| Common GO terms | GO:0000082 - G1/S transition of mitotic cell cycle GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0004672 - protein kinase activity GO:0005634 - nucleus GO:0005654 - nucleoplasm and 9 others more... |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
|
|
|||||||||||||
| + | Hs |   |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Mm | |
|
|||||||||||
| + | At | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | At | |
|
|||||||||||
| + | At | |
|
|||||||||||
| + | At | |
|
|||||||||||
| + | At | |
|
|||||||||||
| + | At | |
|
|||||||||||
| + | At | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | At | |
|
|||||||||||
| + | At | |
|
|||||||||||
| + | At | |
|
|||||||||||
| + | At | |
|
|||||||||||
| + | At | |
|
|||||||||||
| + | At | |
|
|||||||||||
| + | At | |
|
|||||||||||
| + | At | |
|
|||||||||||
Service provided by Combinatics, Japan
Last updated: 11Aug2025
