HitPredict

Interactor 1: MPIP2 (P30305)
M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B)
Gene: CDC25B

Interactor 2: CDK5 (Q00535)
Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)
Gene: CDK5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	22899714, 11516829
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Pkinase~Rhodanese
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006468 - protein phosphorylation and 1 others more... GO:0051301 - cell division
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 580 Hs			1 292
+	Hs
		625159 MPIP2_HUMAN (1-580): 0: 823: 100.00		CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39
+	Hs
		673468 MPIP2_HUMAN (1-580): 0: 823: 100.00		CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30
+	Rn
		823142 MPIP2_RAT (1-580): 0: 830: 79.66		CDK5_RAT (1-292): 3.55e-138: 393: 99.32
+	Hs
		414768 MPIP2_HUMAN (1-580): 0: 823: 100.00		CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01
+	Hs
		673470 MPIP2_HUMAN (1-580): 0: 823: 100.00		CDK16_HUMAN (1-286): 1.11e-115: 343: 57.99
+	Hs
		625158 MPIP1_HUMAN (46-578): 0: 636: 44.73		CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39
+	Hs
		673388 MPIP1_HUMAN (46-578): 0: 636: 44.73		CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30
+	Hs
		673389 MPIP1_HUMAN (46-578): 0: 636: 44.73		CDK5_HUMAN (1-292): 6.09e-139: 395: 100.00
+	Hs
		414767 MPIP1_HUMAN (46-578): 0: 636: 44.73		CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01
+	Rn
		823140 MPIP1_RAT (45-578): 0: 618: 42.59		CDK5_RAT (1-292): 3.55e-138: 393: 99.32
+	Hs
		625160 MPIP3_HUMAN (160-577): 2.99e-146: 432: 35.10		CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39
+	Hs
		673567 MPIP3_HUMAN (160-577): 2.99e-146: 432: 35.10		CDK5_HUMAN (1-292): 6.09e-139: 395: 100.00
+	Hs
		414769 MPIP3_HUMAN (160-577): 2.99e-146: 432: 35.10		CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01
+	Rn
		89020 D4ADT2_RAT (65-577): 4.62e-108: 333: 31.75		CDK5_RAT (1-292): 3.55e-138: 393: 99.32
+	Mm
		509473 MPIP3_MOUSE (205-577): 2.24e-103: 321: 33.65		CDK1_MOUSE (1-289): 2.16e-133: 381: 56.70
+	Dm
		618386 TWINE_DROME (342-564): 3.87e-87: 278: 38.66		CDK1_DROME (1-287): 4.06e-130: 373: 56.40
+	Sp
		383444 MPIP_SCHPO (311-552): 6.87e-61: 213: 34.82		CDK1_SCHPO (1-290): 7.99e-128: 367: 52.35
+	Sc
		339449 MPIP_YEAST (412-575): 3.1e-55: 197: 37.08		CDK1_YEAST (1-288): 1.39e-123: 356: 55.44