Protein: VPS18
Vacuolar protein sorting-associated protein 18 homolog (hVPS18)

Gene: VPS18
Organism: Homo sapiens
Interactions: 137
UniProt ID: Q9P253

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005764 - lysosome
GO:0005765 - lysosomal membrane
GO:0005768 - endosome
GO:0005769 - early endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

888821

VPS41
Vacuolar protein sorting-associated protein 41 homolog

10

18

Small-scale

0.758

High

1431601

VPS11
Vacuolar protein sorting-associated protein 11 homolog

11

20

Small-scale

0.756

High

1383697

VP33A
Vacuolar protein sorting-associated protein 33A

9

17

Small-scale

0.749

High

1431583

VPS16
Vacuolar protein sorting-associated protein 16 homolog

6

13

Small-scale

0.740

High

1356712

TGFA1
Transforming growth factor-beta receptor-associated protein 1

4

16

High-throughput

0.691

High

1454287

PKHM1
Pleckstrin homology domain-containing family M member 1

3

3

Small-scale

0.674

High

1325283

VPS8
Vacuolar protein sorting-associated protein 8 homolog

3

7

Small-scale

0.656

High

901636

RAB7A
Ras-related protein Rab-7a

3

17

Small-scale

0.646

High

175530

TCPR2
Tectonin beta-propeller repeat-containing protein 2

2

1

High-throughput

0.628

High

189893

STX7
Syntaxin-7

2

14

Small-scale

0.612

High

1454277

UVRAG
UV radiation resistance-associated gene protein

2

3

Small-scale

0.611

High

1356628

CT55
Cancer/testis antigen 55

3

1

High-throughput

0.609

High

631526

RAB5A
Ras-related protein Rab-5A

2

15

High-throughput

0.584

High

1452991

GGA3
ADP-ribosylation factor-binding protein GGA3

1

3

Small-scale

0.578

High

835412

VIPR2
Vasoactive intestinal polypeptide receptor 2

2

2

High-throughput

0.574

High

1334422

UXS1
UDP-glucuronic acid decarboxylase 1

2

1

High-throughput

0.574

High

1454281

GGA2
ADP-ribosylation factor-binding protein GGA2

1

3

Small-scale

0.561

High

1454282

GGA1
ADP-ribosylation factor-binding protein GGA1

1

3

Small-scale

0.561

High

138531

BIN1
Myc box-dependent-interacting protein 1

1

2

High-throughput

0.536

High

402694

ALDOA
Fructose-bisphosphate aldolase A

1

1

High-throughput

0.536

High

935216

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.536

High

1116083

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

2

High-throughput

0.536

High

1294918

ZGRF1
5'-3' DNA helicase ZGRF1

1

3

High-throughput

0.536

High

1325849

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

2

High-throughput

0.536

High

1394869

VPS39
Vam6/Vps39-like protein

1

16

Small-scale

0.536

High

1420245

UBXN6
UBX domain-containing protein 6

1

1

High-throughput

0.536

High

1420854

SEM4C
Semaphorin-4C

1

1

High-throughput

0.536

High

1448509

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.536

High

1454286

SYNP2
Synaptopodin-2

1

0

Small-scale

0.529

High

1398895

RILP
Rab-interacting lysosomal protein

1

3

Small-scale

0.527

High

1417978

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

0

High-throughput

0.518

High

943146

STX17
Syntaxin-17

1

4

Small-scale

0.515

High

401619

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.513

High

1102670

MTA1
Metastasis-associated protein MTA1

1

0

High-throughput

0.513

High

1206657

TJAP1
Tight junction-associated protein 1

1

0

High-throughput

0.513

High

1361109

CCG8
Voltage-dependent calcium channel gamma-8 subunit

1

0

High-throughput

0.513

High

1448993

SERC1
Serine incorporator 1

1

0

High-throughput

0.513

High

1271337

MON1B
Vacuolar fusion protein MON1 homolog B

1

8

Small-scale

0.504

High

982347

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

3

Small-scale

0.501

High

1159651

STX1A
Syntaxin-1A

1

13

Small-scale

0.501

High

280965

HYPM
Huntingtin-interacting protein M

1

1

High-throughput

0.489

High

296839

ST1C4
Sulfotransferase 1C4

1

1

High-throughput

0.489

High

298965

DNJB5
DnaJ homolog subfamily B member 5

1

4

High-throughput

0.489

High

909218

NEK4
Serine/threonine-protein kinase Nek4

1

2

High-throughput

0.489

High

914361

EFNA4
Ephrin-A4

1

2

High-throughput

0.489

High

1161245

MK06
Mitogen-activated protein kinase 6

1

2

High-throughput

0.489

High

1350476

BICD2
Protein bicaudal D homolog 2

1

1

High-throughput

0.489

High

1369656

PMM1
Phosphomannomutase 1

1

1

High-throughput

0.489

High

1397677

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.489

High

1402729

TCPQM
T-complex protein 1 subunit theta-like 2

1

1

High-throughput

0.489

High

1403461

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.489

High

1431157

GHC2
Mitochondrial glutamate carrier 2

1

1

High-throughput

0.489

High

1434765

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

1

High-throughput

0.489

High

1454283

CC018
Uncharacterized protein C3orf18

1

3

High-throughput

0.489

High

921817

COPB
Coatomer subunit beta

1

5

High-throughput

0.481

High

218892

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.479

High

412725

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

562457

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.479

High

631000

RAB4A
Ras-related protein Rab-4A

1

8

High-throughput

0.479

High

831563

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

863009

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

2

High-throughput

0.479

High

902119

RAB9A
Ras-related protein Rab-9A

1

15

High-throughput

0.479

High

976623

RB11A
Ras-related protein Rab-11A

1

5

High-throughput

0.479

High

1233540

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.479

High

1255890

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.479

High

1276347

ATG9A
Autophagy-related protein 9A

1

3

High-throughput

0.479

High

1367461

ESR2
Estrogen receptor beta

1

3

High-throughput

0.479

High

1383410

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

3

High-throughput

0.479

High

1436472

AKTIP
AKT-interacting protein

1

5

Small-scale

0.479

High

1454278

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

1

6

High-throughput

0.479

High

1454279

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1454280

HOOK1
Protein Hook homolog 1

1

6

Small-scale

0.479

High

1067783

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.460

High

1141985

EEA1
Early endosome antigen 1

1

0

High-throughput

0.458

High

166432

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

1

High-throughput

0.445

High

877724

SL9A3
Sodium/hydrogen exchanger 3

1

1

High-throughput

0.445

High

1329204

S15A4
Solute carrier family 15 member 4

1

1

High-throughput

0.445

High

1366283

LPAR1
Lysophosphatidic acid receptor 1

1

3

High-throughput

0.445

High

1404966

S1PR3
Sphingosine 1-phosphate receptor 3

1

3

High-throughput

0.445

High

1451737

OCAD1
OCIA domain-containing protein 1

1

1

High-throughput

0.445

High

106775

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

316098

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.437

High

457995

TRY1
Serine protease 1

1

3

High-throughput

0.437

High

461994

HS90A
Heat shock protein HSP 90-alpha

1

5

High-throughput

0.437

High

468865

HS90B
Heat shock protein HSP 90-beta

1

5

High-throughput

0.437

High

1314716

SRRM1
Serine/arginine repetitive matrix protein 1

1

2

High-throughput

0.437

High

1365522

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

1

High-throughput

0.437

High

1394565

RSRC1
Serine/Arginine-related protein 53

1

1

High-throughput

0.437

High

1402619

SRPK1
SRSF protein kinase 1

1

3

High-throughput

0.437

High

1429581

LSG1
Large subunit GTPase 1 homolog

1

4

High-throughput

0.437

High

72600

A9Z1X7
Serine/arginine repetitive matrix protein 1

1

1

High-throughput

0.407

High

114458

H0Y8D1
Serine protease 1

1

3

High-throughput

0.407

High

116555

H7C5Q0
Arginine and serine rich coiled-coil 1

1

1

High-throughput

0.407

High

171599

S27A2
Long-chain fatty acid transport protein 2

1

5

High-throughput

0.407

High

437811

HEPS
Serine protease hepsin

1

1

High-throughput

0.407

High

466983

ACM4
Muscarinic acetylcholine receptor M4

1

1

High-throughput

0.407

High

621540

HXK1
Hexokinase-1

1

1

High-throughput

0.407

High

653630

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.407

High

683355

TNR5
Tumor necrosis factor receptor superfamily member 5

1

1

High-throughput

0.407

High

886146

CXCR3
C-X-C chemokine receptor type 3

1

3

High-throughput

0.407

High

1153450

CD226
CD226 antigen

1

1

High-throughput

0.407

High

1167127

WHAL1
Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1

1

1

High-throughput

0.407

High

1253672

PKHG7
Pleckstrin homology domain-containing family G member 7

1

2

High-throughput

0.407

High

1279097

RIC3
Protein RIC-3

1

1

High-throughput

0.407

High

1384961

CC127
Coiled-coil domain-containing protein 127

1

2

High-throughput

0.407

High

1398007

MF14A
Hippocampus abundant transcript 1 protein

1

2

High-throughput

0.407

High

1431276

DJC25
DnaJ homolog subfamily C member 25

1

3

High-throughput

0.407

High

1454285

FZD10
Frizzled-10

1

2

High-throughput

0.407

High

181025

LRAD4
Low-density lipoprotein receptor class A domain-containing protein 4

3

0

High-throughput

0.347

High

1248591

LYPD4
Ly6/PLAUR domain-containing protein 4

2

0

High-throughput

0.328

High

194425

GR6
Protein GR6

1

0

High-throughput

0.279

Low

216841

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.279

Low

261564

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.279

Low

300850

KRT38
Keratin, type I cuticular Ha8

1

0

High-throughput

0.279

Low

359884

DYR
Dihydrofolate reductase

1

0

High-throughput

0.279

Low

690057

CRBB3
Beta-crystallin B3

1

0

High-throughput

0.279

Low

777575

K22E
Keratin, type II cytoskeletal 2 epidermal

1

0

High-throughput

0.279

Low

940092

NDUV3
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

1

0

High-throughput

0.279

Low

1163948

UPP1
Uridine phosphorylase 1

1

0

High-throughput

0.279

Low

1178906

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.279

Low

1206167

TGO1
Transport and Golgi organization protein 1 homolog

1

0

High-throughput

0.279

Low

1217430

OBSCN
Obscurin

1

0

High-throughput

0.279

Low

1313713

IFT20
Intraflagellar transport protein 20 homolog

1

0

High-throughput

0.279

Low

1335496

SEN2
tRNA-splicing endonuclease subunit Sen2

1

0

High-throughput

0.279

Low

1384671

ELMO3
Engulfment and cell motility protein 3

1

0

High-throughput

0.279

Low

1393924

SCLY
Selenocysteine lyase

1

0

High-throughput

0.279

Low

1396458

F167A
Protein FAM167A

1

0

High-throughput

0.279

Low

1417892

DUS16
Dual specificity protein phosphatase 16

1

0

High-throughput

0.279

Low

1454284

MED23
Mediator of RNA polymerase II transcription subunit 23

1

0

High-throughput

0.279

Low

1007657

CCNA1
Cyclin-A1

1

0

High-throughput

0.269

Low

1229728

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

1399031

YI001
Uncharacterized protein FLJ30774

1

0

High-throughput

0.249

Low

1434102

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

143761

WN10B
Protein Wnt-10b

1

0

High-throughput

0.232

Low

896463

ERF
ETS domain-containing transcription factor ERF

1

0

High-throughput

0.232

Low

1244122

TMM88
Transmembrane protein 88

1

0

High-throughput

0.232

Low

1332140

CI163
Uncharacterized protein C9orf163

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025