Protein: VPS8
Vacuolar protein sorting-associated protein 8 homolog

Gene: VPS8
Organism: Homo sapiens
Interactions: 81
UniProt ID: Q8N3P4

Gene Ontology (top 5):
GO:0005769 - early endosome
GO:0005770 - late endosome
GO:0006623 - protein targeting to vacuole
GO:0008270 - zinc ion binding
GO:0030897 - HOPS complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1325269

TGFA1
Transforming growth factor-beta receptor-associated protein 1

5

7

Small-scale

0.712

High

1325279

VPS11
Vacuolar protein sorting-associated protein 11 homolog

4

7

Small-scale

0.694

High

1325278

VPS16
Vacuolar protein sorting-associated protein 16 homolog

3

2

Small-scale

0.667

High

1325283

VPS18
Vacuolar protein sorting-associated protein 18 homolog

3

7

Small-scale

0.656

High

1325270

VP33A
Vacuolar protein sorting-associated protein 33A

2

2

High-throughput

0.611

High

835327

VIPR2
Vasoactive intestinal polypeptide receptor 2

3

1

High-throughput

0.604

High

631338

RAB5A
Ras-related protein Rab-5A

2

6

High-throughput

0.584

High

845455

PE2R3
Prostaglandin E2 receptor EP3 subtype

2

1

High-throughput

0.558

High

638471

FPR1
fMet-Leu-Phe receptor

2

2

High-throughput

0.549

High

630881

RAB4A
Ras-related protein Rab-4A

2

1

High-throughput

0.533

High

976409

RB11A
Ras-related protein Rab-11A

2

1

High-throughput

0.533

High

166346

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

2

0

High-throughput

0.528

High

210408

MTLR
Motilin receptor

1

2

High-throughput

0.489

High

640417

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

1

High-throughput

0.489

High

719810

V2R
Vasopressin V2 receptor

1

1

High-throughput

0.489

High

867987

GLR
Glucagon receptor

1

2

High-throughput

0.489

High

1101583

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

1

High-throughput

0.489

High

1142100

P2RY6
P2Y purinoceptor 6

1

1

High-throughput

0.489

High

1325290

GPR45
Probable G-protein coupled receptor 45

1

1

High-throughput

0.489

High

189701

STX7
Syntaxin-7

1

1

High-throughput

0.479

High

900916

RAB5C
Ras-related protein Rab-5C

1

6

High-throughput

0.479

High

901384

RAB7A
Ras-related protein Rab-7a

1

3

High-throughput

0.479

High

901935

RAB9A
Ras-related protein Rab-9A

1

2

High-throughput

0.479

High

412253

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

562219

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.458

High

1254621

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1276214

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.458

High

1325284

ANFY1
Rabankyrin-5

1

0

High-throughput

0.458

High

1325286

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

945041

RAB25
Ras-related protein Rab-25

1

1

High-throughput

0.437

High

946834

H2B1D
Histone H2B type 1-D

1

1

High-throughput

0.437

High

1140551

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.437

High

171510

S27A2
Long-chain fatty acid transport protein 2

1

2

High-throughput

0.407

High

704042

5HT1E
5-hydroxytryptamine receptor 1E

1

1

High-throughput

0.407

High

732933

GASR
Gastrin/cholecystokinin type B receptor

1

1

High-throughput

0.407

High

886101

CXCR3
C-X-C chemokine receptor type 3

1

1

High-throughput

0.407

High

1208856

H2B2F
Histone H2B type 2-F

1

1

High-throughput

0.407

High

1234018

S35E4
Solute carrier family 35 member E4

1

1

High-throughput

0.407

High

1240899

S27A4
Long-chain fatty acid transport protein 4

1

2

High-throughput

0.407

High

1243629

S27A1
Long-chain fatty acid transport protein 1

1

2

High-throughput

0.407

High

906111

AL3A2
Aldehyde dehydrogenase family 3 member A2

3

0

High-throughput

0.347

High

1325288

FZD10
Frizzled-10

3

0

High-throughput

0.345

High

665321

EDNRB
Endothelin receptor type B

2

0

High-throughput

0.328

High

1325266

KIF2B
Kinesin-like protein KIF2B

2

0

High-throughput

0.328

High

1325267

SIGL1
SIGLEC family-like protein 1

2

0

High-throughput

0.328

High

1325268

UXS1
UDP-glucuronic acid decarboxylase 1

2

0

High-throughput

0.328

High

1325265

PNKD
Probable thioesterase PNKD

2

0

High-throughput

0.318

High

71228

HIDE1
Protein HIDE1

1

0

High-throughput

0.279

Low

209064

CYB5B
Cytochrome b5 type B

1

0

High-throughput

0.279

Low

388246

GLPA
Glycophorin-A

1

0

High-throughput

0.279

Low

755596

TTK
Dual specificity protein kinase TTK

1

0

High-throughput

0.279

Low

925948

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

0

High-throughput

0.279

Low

1022908

EFNB1
Ephrin-B1

1

0

High-throughput

0.279

Low

1216383

FAXC
Failed axon connections homolog

1

0

High-throughput

0.279

Low

1232696

H2A2A
Histone H2A type 2-A

1

0

High-throughput

0.279

Low

1249811

BTNL9
Butyrophilin-like protein 9

1

0

High-throughput

0.279

Low

1291626

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

0

High-throughput

0.279

Low

1309786

IPRI
Inositol 1,4,5-trisphosphate receptor-interacting protein

1

0

High-throughput

0.279

Low

1325271

RUSF1
RUS family member 1

1

0

High-throughput

0.279

Low

1325275

KI2L4
Killer cell immunoglobulin-like receptor 2DL4

1

0

High-throughput

0.279

Low

1325276

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.279

Low

1325277

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.279

Low

1325285

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

1325287

CC018
Uncharacterized protein C3orf18

1

0

High-throughput

0.279

Low

181908

SMAD9
Mothers against decapentaplegic homolog 9

1

0

High-throughput

0.265

Low

218452

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

1159750

OCLN
Occludin

1

0

High-throughput

0.249

Low

1233347

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.249

Low

1293484

COMD2
COMM domain-containing protein 2

1

0

High-throughput

0.249

Low

1325272

SPTCS
Spatacsin

1

0

Small-scale

0.238

Low

1325280

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.238

Low

47017

A0A494C104
Nucleoporin 214

1

0

High-throughput

0.232

Low

50617

HACL2
2-hydroxyacyl-CoA lyase 2

1

0

High-throughput

0.232

Low

683282

TNR5
Tumor necrosis factor receptor superfamily member 5

1

0

High-throughput

0.232

Low

1147791

DHC24
Delta(24)-sterol reductase

1

0

High-throughput

0.232

Low

1279055

RIC3
Protein RIC-3

1

0

High-throughput

0.232

Low

1325273

S35E1
Solute carrier family 35 member E1

1

0

High-throughput

0.232

Low

1325274

S1PR3
Sphingosine 1-phosphate receptor 3

1

0

High-throughput

0.232

Low

1325281

S22AB
Solute carrier family 22 member 11

1

0

High-throughput

0.232

Low

1325282

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.232

Low

1325289

XCT
Cystine/glutamate transporter

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025