HitPredict

Interactor 1: METK2 (P31153)
S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) (Methionine adenosyltransferase II) (MAT-II)
Gene: MAT2A

Interactor 2: METK1 (Q00266)
S-adenosylmethionine synthase isoform type-1 (AdoMet synthase 1) (EC 2.5.1.6) (Methionine adenosyltransferase 1) (MAT 1) (Methionine adenosyltransferase I/III) (MAT-I/III)
Gene: MAT1A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.85 1.00 0.926

The method score is based on:

Property Details
Experiments 26186194, 28514442, 32296183, 33961781, unassigned1304
Identification Methods affinity chromatography technology, two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains S-AdoMet_synt_C~S-AdoMet_synt_C, S-AdoMet_synt_C~S-AdoMet_synt_M, S-AdoMet_synt_C~S-AdoMet_synt_N, S-AdoMet_synt_M~S-AdoMet_synt_M, S-AdoMet_synt_M~S-AdoMet_synt_N, S-AdoMet_synt_N~S-AdoMet_synt_N
Common GO terms GO:0004478 - methionine adenosyltransferase activity
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0006556 - S-adenosylmethionine biosynthetic process
GO:0006730 - one-carbon metabolic process
and 2 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 395
Hs

1 395
+ Hs
+ Hs
+ Rn
+ Sc
+ Sc
+ Zm
+ Ce
+ Ce
+ Sc
+ Ce
+ Sp
+ Ce
+ Dm
+ Ec
+ Pf
+ Cj

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Last updated: 15 Jul 2024