HitPredict

Interactor 1: TLX1 (P31314)
T-cell leukemia homeobox protein 1 (Homeobox protein Hox-11) (Proto-oncogene TCL-3) (T-cell leukemia/lymphoma protein 3)
Gene: TLX1

Interactor 2: SMCA2 (P51531)
Probable global transcription activator SNF2L2 (EC 3.6.4.-) (ATP-dependent helicase SMARCA2) (BRG1-associated factor 190B) (BAF190B) (Protein brahma homolog) (hBRM) (SNF2-alpha) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2)
Gene: SMARCA2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 330 Hs			1 1590
+	Hs
		211811 TLX3_HUMAN (11-325): 9.96e-34: 127: 47.94		SMCA2_HUMAN (1-1590): 0: 1088: 100.00
+	Mm
		590370 PO5F1_MOUSE (32-327): 1.17e-33: 128: 15.15		SMCA2_MOUSE (1-1590): 0: 1055: 94.38
+	Hs
		846727 LBX1_HUMAN (194-274): 6.78e-15: 75.5: 51.85		SMCA2_HUMAN (1-1590): 0: 1088: 100.00
+	Mm
		590316 PO5F1_MOUSE (32-327): 1.17e-33: 128: 15.15		SMCA4_MOUSE (40-1588): 0: 986: 72.81
+	Dm
		631291 UBX_DROME (65-265): 4.1e-33: 128: 23.83		BRM_DROME (21-1578): 0: 881: 50.85
+	Hs
		658737 NANOG_HUMAN (133-316): 2.34e-38: 140: 25.89		SMCA1_HUMAN (618-1559): 0: 797: 28.00
+	Mm
		590474 PO5F1_MOUSE (32-327): 1.17e-33: 128: 15.15		SMCA5_MOUSE (613-1584): 0: 803: 27.51
+	Mm
		590383 PO5F1_MOUSE (32-327): 1.17e-33: 128: 15.15		CHD4_MOUSE (370-1589): 0: 740: 22.21
+	Mm
		69793 PO5F1_MOUSE (32-327): 1.17e-33: 128: 15.15		B1AR17_MOUSE (403-1586): 0: 738: 23.11
+	Hs
		213362 TLX2_HUMAN (4-327): 2e-39: 142: 50.89		CHD6_HUMAN (315-1363): 0: 711: 24.12
+	Mm
		56898 PO5F1_MOUSE (32-327): 1.17e-33: 128: 15.15		CHD5_MOUSE (409-1579): 0: 716: 22.28
+	Dm
		332756 UBX_DROME (65-265): 4.1e-33: 128: 23.83		CHDM_DROME (333-1579): 0: 711: 21.17
+	Hs
		211924 TLX3_HUMAN (11-325): 9.96e-34: 127: 47.94		CHD6_HUMAN (315-1363): 0: 711: 24.12
+	Hs
		1059707 ZFHX4_HUMAN (163-287): 8.25e-12: 68.5: 17.19		CHD4_HUMAN (370-1589): 0: 749: 22.31
+	Hs
		1018559 ZFHX4_HUMAN (163-287): 8.25e-12: 68.5: 17.19		CHD3_HUMAN (415-1590): 0: 725: 23.92
+	Mm
		590444 PO5F1_MOUSE (32-327): 1.17e-33: 128: 15.15		EP400_MOUSE (1048-1192): 6.84e-45: 181: 39.31
+	Hs
		679182 TLX1_HUMAN (1-330): 1.72e-60: 198: 100.00		CHD7_HUMAN (123-733): 1.37e-11: 72.1: 7.20
+	Hs
		213398 TLX2_HUMAN (4-327): 2e-39: 142: 50.89		CHD7_HUMAN (123-733): 1.37e-11: 72.1: 7.20
+	Hs
		967993 PO5F1_HUMAN (31-327): 1.93e-33: 128: 17.00		CHD7_HUMAN (123-733): 1.37e-11: 72.1: 7.20
+	Hs
		211986 TLX3_HUMAN (11-325): 9.96e-34: 127: 47.94		CHD7_HUMAN (123-733): 1.37e-11: 72.1: 7.20