Interactor 1: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Interactor 2: NOTC1 (P46531)
Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]
Gene: NOTCH1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.58 1.00 0.767

The method score is based on:

Property Details
Experiments 27229929, 18440314
Identification Methods two hybrid, enzymatic study
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Ank~Pkinase, Ank_2~Pkinase, Ank_4~Pkinase
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0006606 - protein import into nucleus
and 6 others

more...

Homologous interactions 2

Homologous interactions

Color coding for hit scores

1 480
Hs

1 2555
+ Dm
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024