HitPredict

Interactor 1: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Interactor 2: GSK3B (P49841)
Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)
Gene: GSK3B

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.989

The method score is based on:

Property Details
Experiments 15688030, 18505846, 8524413, 17428466, 14701753, 22337773, 27563096, 29464284, 16009706, 19995607, 16123141, 15470047, 20856200, 14645548, 20682768, 19713527, 23824745, 16282323, 17693255, 23010592
Identification Methods enzymatic study, affinity chromatography technology, pull down, protein kinase assay, in-gel kinase assay, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type direct interaction, physical association, phosphorylation reaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains PH~Pkinase, Pkinase~Pkinase, Pkinase~Pkinase_C
Common GO terms GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 22 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 480
Hs

1 420
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Last updated: 15 Jul 2024