HitPredict

Interactor 1: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Interactor 2: GSK3A (P49840)
Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1)
Gene: GSK3A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.979

The method score is based on:

Property Details
Experiments 21775285, 16998585, 22504172, 14701753, 11546794, 29464284, 33478005, 34941261, 19995607, 11509608, 17505062, 14645548, 15678105
Identification Methods enzymatic study, affinity chromatography technology
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PH~Pkinase, Pkinase~Pkinase, Pkinase~Pkinase_C
Common GO terms GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
and 14 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 480
Hs

1 483
+ Rn
+ Rn
+ Mm
+ Hs
+ Mm
+ Hs
+ Mm
+ Hs
+ Mm
+ Hs
+ Ce
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024