HitPredict

Interactor 1: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Interactor 2: F263 (Q16875)
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (6PF-2-K/Fru-2,6-P2ase 3) (PFK/FBPase 3) (6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme) (Renal carcinoma antigen NY-REN-56) (iPFK-2) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]
Gene: PFKFB3

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	15896703
Identification Methods	in-gel kinase assay
Interaction Type	phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 480 Hs			1 520
+	Hs
		566406 KPCA_HUMAN (14-477): 1.41e-151: 448: 36.27		F263_HUMAN (1-520): 0: 805: 100.00
+	Hs
		555729 AKT1_HUMAN (1-480): 0: 586: 100.00		F261_HUMAN (4-455): 0: 639: 70.40
+	Bt
		382198 KPCA_BOVIN (14-477): 7.97e-151: 447: 36.27		F262_BOVIN (29-475): 0: 646: 73.27
+	Hs
		555725 KPCA_HUMAN (14-477): 1.41e-151: 448: 36.27		F261_HUMAN (4-455): 0: 639: 70.40
+	Bt
		337289 KAPCA_BOVIN (138-445): 9.54e-144: 417: 42.21		F262_BOVIN (29-475): 0: 646: 73.27
+	Hs
		555726 KAPCA_HUMAN (138-445): 1.76e-144: 419: 42.53		F261_HUMAN (4-455): 0: 639: 70.40
+	Hs
		430415 AKT1_HUMAN (1-480): 0: 586: 100.00		PMGE_HUMAN (244-442): 6.72e-59: 197: 21.51
+	Dm
		220901 AKT1_DROME (3-474): 0: 523: 60.37		PGAM5_DROME (245-427): 1.06e-41: 152: 20.64
+	Hs
		850700 KS6A3_HUMAN (36-455): 4.1e-103: 325: 23.01		PGAM5_HUMAN (215-426): 2.64e-51: 178: 17.05